Results 61 to 70 of about 26,973 (242)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

«Non sufficit orbis». Mobilizing Imageries, Global Catholicism and Imperial Propaganda in the Widened Worlds of the Habsburgs in the Early Modern Age

Intrecci d'arte
Under Philip II, the Habsburg Empire reached across the globe a complex confederation that spanned the Atlantic Ocean and included high-tension European areas.
Maria Vittoria Spissu
doaj   +1 more source

Les connecteurs, de la grammaire à la littéracie

Lidil, 2017
The evaluations of the skills of the learners in French constitute revelations of their difficulties, in particular in their knowledge of the language and in four skills.
Sabina Mahmudova
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A Universal Electric Vehicle Outlet and Portable Cable for North America

World Electric Vehicle Journal
For electric vehicle (EV) charging in North America, three AC connectors are standardized, resulting in a proliferation of charging stations which can only charge one of the three types of EV.
Willett Kempton, Rodney T. McGee, Garrett A. Ejzak   +2 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Taming Hierarchical Connectors

, 2019
Building and maintaining complex systems requires good software engineering practices, including code modularity and reuse. The same applies in the context of coordination of complex component-based systems. This paper investigates how to verify properties of complex coordination patterns built hierarchically, i.e., built from composing blocks that are
Proenca, José, Madeira, Alexandre
openaire   +4 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Analysis and Mitigation of Stray Capacitance Effects in Resistive High-Voltage Dividers

Energies, 2019
This work analyzes the effects of the parasitic or stray distributed capacitance to ground in high-voltage environments and assesses the effectiveness of different corrective actions to minimize such effects.
Jordi-Roger Riba, Francesca Capelli, Manuel Moreno-Eguilaz   +2 more
doaj   +1 more source