Results 71 to 80 of about 55,399 (296)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2011 This thesis presents a new concept in steel-concrete-steel sandwich construction in which a bi-directional corrugated-strip core is proposed as an alternative inclined shear connector.
Leekitwattana, M.
core +1 more source
A Theory of Mediators for Eternal Connectors [PDF]
, 2010 International audienceOn the fly synthesis of mediators is a revolutionary approach to the seamless networking of today's and future digital systems that increasingly need be connected.
Inverardi, Paola +2 more
core +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The resistances of stud shear connectors with profiled sheeting [PDF]
This thesis presents the study of the static behaviour of stud shear connectors welded through profiled sheeting and the fatigue resistances of the connectors in composite bridges.
Yuan, Hui
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Towards a Connector Algebra [PDF]
, 2010 Interoperability of heterogeneous networked systems has yet to reach the maturity required by ubiquitous computing due to the technology-dependent nature of solutions. The CONNECT Integrated Project attempts to develop a novel network infrastructure to allow heterogeneous networked systems to freely communicate with one another by synthesising the ...
AUTILI, Marco +4 more
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Towards a Formalization of Mediating Connectors for on the Fly Interoperability [PDF]
, 2009 International audienceMediators stand as a core architectural paradigm for today's and future systems that increasingly need to be connected. The mediator concept has been used to cope with many heterogeneity dimensions.
Valerie Issarny +5 more
core +1 more source