Results 211 to 220 of about 75,295 (332)

Blockade of P2X7 receptors preserves blood retinal barrier integrity by modulating the plasmalemma vesicle‐associated protein: Implications for diabetic retinopathy

British Journal of Pharmacology, Volume 182, Issue 12, Page 2603-2620, June 2025.
Background and Purpose Plasmalemma vesicle‐associated protein (PLVAP) regulates transcytosis in vascular endothelial cells. PLVAP expression is increased in pathological conditions, such as diabetic retinopathy. P2X7 receptor antagonists have been shown to preserve blood‐retinal barrier (BRB) integrity.
Chiara Bianca Maria Platania, Francesca Lazzara, Kenneth Mitton, Naomi Haque, Wendelin Dailey, Federica Conti, Erika Giuffrida, Filippo Drago, Anca Hermenean, Cornel Balta, Hildegard Herman, Alina Ciceu, Maria Consiglia Trotta, Michele D'Amico, Giuseppe Nicosia, Settimio Rossi, Claudio Bucolo   +16 more
wiley   +1 more source

Spatial Transcriptomics Shows a Distinctive Tumour Microenvironment in the Invasive Versus Premalignant Portion of Early Cutaneous Squamous Cell Carcinoma

Experimental Dermatology, Volume 34, Issue 6, June 2025.
In this study, we compared gene expression patterns between the premalignant actinic keratosis (AK) and invasive cutaneous squamous cell carcinoma (SCC) portions within early‐stage cutaneous SCC tissue samples. We identified 29, 14, and 15 differentially expressed genes (DEGs) between the invasive SCC and premalignant AK portions in tumor cells, immune
Jeong‐An Gim, Chungyeul Kim, Hyun Jyung Oh, Ko Eun Kim, Jiehyun Jeon, Aeree Kim, Yoo Sang Baek   +6 more
wiley   +1 more source

The connexins

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2004
openaire   +3 more sources

A connexin 26 mutation causes a syndrome of sensorineural hearing loss and palmoplantar hyperkeratosis (MIM 148350) [PDF]

, 2000
Kirsten Heathcote
openalex   +1 more source

Adiponectin and gastric fundus: A potential target for gut–brain axis dysfunctions

Physiological Reports, Volume 13, Issue 11, June 2025.
Abstract Adiponectin (ADPN) is a pleiotropic hormone produced by adipose tissue involved in the control of body weight, energy expenditure, and feeding behaviors. Alongside a central effect, ADPN acts on peripheral organs such as the stomach, where it can favor gastric fundus relaxation, reinforcing central satiety signals.
R. Garella, F. Palmieri, F. Chellini, L. Tarchi, V. Ricca, G. Castellini, C. Sassoli, R. Squecco   +7 more
wiley   +1 more source

Bone-Resorbing Osteoclasts Contain Gap-Junctional Connexin-43 [PDF]

, 2000
Joanna Ilvesaro, Kalervo Väänänen, Juha Tuukkanen   +2 more
openalex   +1 more source

Histone Deacetylase 6 Controls Atrial Fibrosis and Remodeling in Postinfarction Mice Through the Modulation of Wnt3a/GSK‐3β Signaling

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
Elevated levels of HDAC6 activate the Wnt3a/GSK3β signaling pathway, leading to the phosphorylation of GSK3β and its subsequent binding to HDAC6, followed by translocation into the mitochondria. Within the mitochondria, GSK3β interacts with TFAM, competitively reducing TFAM's binding to mtDNA. This reduction decreases mtDNA transcription and stability,
Shangzhi Shu, Junqiao Fang, Longguo Zhao, Jiatong Han, Meiping Zhang, Chaoqun Huang, Xian Wu Cheng, Shuyan Li   +7 more
wiley   +1 more source

Connexin 43-Enhanced Suicide Gene Therapy Using Herpesviral Vectors [PDF]

, 2000
Peggy Marconi, Masakazu Tamura, Shusuke Moriuchi, David Krisky, Ajay Niranjan, William F. Goins, Justus B. Cohen, Joseph C. Glorioso   +7 more
openalex   +1 more source

Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis

Glia, 2016
Akshata A Almad, A. Doreswamy, Sarah K Gross, J. Richard, Y. Huo, N. Haughey, N. Maragakis   +6 more
semanticscholar   +1 more source

Connexin-43 Protein Expression Pattern Analysis in Myocardial Infarction Tissues. [PDF]

In Vivo
Tsantoulas A, Roukas D, Mastronikoli S, Tsiambas E, Tsouvelas G, Kafkas N, Fotiades P, Papouliakos S, Agrogiannis G, Lazaris AC, Kavantzas N.   +10 more
europepmc   +1 more source