Results 301 to 310 of about 75,295 (332)
Cell and Tissue Research, 2014 Connexins are essential in the propagation of electrical activity throughout the heart and are an important determinant of conduction velocity. Their dysfunction is an important factor in the genesis of abnormal cardiac rhythm and is relevant to the pathogenesis of a wide variety of cardiac pathologies. Here, we review the basic biology of connexins in
Pier D. Lambiase, Andrew Tinker
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Australasian Journal of Dermatology, 2013
We describe a case of an 18-year-old woman with congenital sensorineural deafness who presented to the dermatology clinic with asymptomatic thickening of the skin over the palmar aspect of her hands and feet. An examination revealed palmoplantar keratoderma of the palms and soles of the feet with no pseudoainhum.
Aamir Memon +3 more
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We describe a case of an 18-year-old woman with congenital sensorineural deafness who presented to the dermatology clinic with asymptomatic thickening of the skin over the palmar aspect of her hands and feet. An examination revealed palmoplantar keratoderma of the palms and soles of the feet with no pseudoainhum.
Aamir Memon +3 more
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Connexins are mechanosensitive
American Journal of Physiology-Cell Physiology, 2004Connexins form gap junction channels that provide a hydrophilic path between cell interiors. Some connexins, particularly the lens connexins, Cx46 and Cx50 and their orthologs, can form functional hemichannels in nonjunctional membranes. These hemichannels are a nonselective conduit to the extracellular medium and may jeopardize cell survival.
Frederick Sachs, Gerhard Dahl, Li Bao
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2006
Remodeling of the vascular wall plays a central role in many physiological processes, but also in the pathogenesis of cardiovascular diseases such as atherosclerosis and restenosis. Atherosclerosis represents the major cause of death and disability in adult populations of Western societies.
Chadjichristos, Christos +2 more
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Remodeling of the vascular wall plays a central role in many physiological processes, but also in the pathogenesis of cardiovascular diseases such as atherosclerosis and restenosis. Atherosclerosis represents the major cause of death and disability in adult populations of Western societies.
Chadjichristos, Christos +2 more
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Biology of the Cell, 2002
Summry— Connexin channels clustered at gap junctions are obligatory attributes of all macroscopic endocrine and exocrine glands investigated so far and also connect most types of cells which produce secretory products in other tissues. Increasing evidence indicates that connexins, and the cell‐to‐cell communications that these proteins permit ...
Alessandra Calabrese +8 more
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Summry— Connexin channels clustered at gap junctions are obligatory attributes of all macroscopic endocrine and exocrine glands investigated so far and also connect most types of cells which produce secretory products in other tissues. Increasing evidence indicates that connexins, and the cell‐to‐cell communications that these proteins permit ...
Alessandra Calabrese +8 more
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Biology of the Cell, 2002
Summry— The hypothesis, that gap junctional intercellular communication plays a key role in carcinogenesis and more generally in growth control was formulated nearly 40 years ago. From this time, data accumulated, showing that this type of communication is frequently decreased or absent in cells treated with tumor promoting agents, among transformed ...
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Summry— The hypothesis, that gap junctional intercellular communication plays a key role in carcinogenesis and more generally in growth control was formulated nearly 40 years ago. From this time, data accumulated, showing that this type of communication is frequently decreased or absent in cells treated with tumor promoting agents, among transformed ...
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Trends in Cardiovascular Medicine, 1992
Gap junctions are specialized regions of adjoining cell membranes composed of numerous intercellular low-resistance channels. In the heart, these channels electrotonically couple adjacent myocytes and synchronize the cardiac action potential. Signaling through gap junction channels may also influence embryogenesis and development.
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Gap junctions are specialized regions of adjoining cell membranes composed of numerous intercellular low-resistance channels. In the heart, these channels electrotonically couple adjacent myocytes and synchronize the cardiac action potential. Signaling through gap junction channels may also influence embryogenesis and development.
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2009
Fundamentals of Connexin Biology.- The Family of Connexin Genes.- Gap Junction Channel Structure.- The Connexin Channel Pore: Pore-Lining Segments and Residues.- Voltage-Gating Mechanisms of Connexin Channels.- Chemical Gating of Connexin Channels.- Electrical Signaling with Neuronal Gap Junctions.- Permeability of Connexin Channels.- Pharmacology of ...
Darren Locke, Andrew L. Harris
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Fundamentals of Connexin Biology.- The Family of Connexin Genes.- Gap Junction Channel Structure.- The Connexin Channel Pore: Pore-Lining Segments and Residues.- Voltage-Gating Mechanisms of Connexin Channels.- Chemical Gating of Connexin Channels.- Electrical Signaling with Neuronal Gap Junctions.- Permeability of Connexin Channels.- Pharmacology of ...
Darren Locke, Andrew L. Harris
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Journal of Animal Science, 2010
During mammalian oogenesis, intercellular communication between oocytes and the surrounding follicle cells through gap junction channels is crucial for oocyte development and maturation. The channel properties of gap junctions may be affected by the composition or combination of connexins, the expression of which is regulated by gonadotropins and other
Jun Miyoshi +9 more
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During mammalian oogenesis, intercellular communication between oocytes and the surrounding follicle cells through gap junction channels is crucial for oocyte development and maturation. The channel properties of gap junctions may be affected by the composition or combination of connexins, the expression of which is regulated by gonadotropins and other
Jun Miyoshi +9 more
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Biochimie, 2010
The role of gap junctions in proliferation, differentiation and apoptosis has been recently highlighted. Nevertheless, the molecular mechanisms that control these physiological events by acting on gap junction channels are still unknown. We have recently demonstrated that heteromeric gap junction plaques composed by Cx43 and Cx33 are unstable at the ...
Dominique Segretain +4 more
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The role of gap junctions in proliferation, differentiation and apoptosis has been recently highlighted. Nevertheless, the molecular mechanisms that control these physiological events by acting on gap junction channels are still unknown. We have recently demonstrated that heteromeric gap junction plaques composed by Cx43 and Cx33 are unstable at the ...
Dominique Segretain +4 more
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