Results 11 to 20 of about 25,696 (242)
Connexin 43 Phosphorylation: Implications in Multiple Diseases
Molecules, 2023 Connexin 43 (Cx43) is most widely distributed in mammals, especially in the cardiovascular and nervous systems. Its phosphorylation state has been found to be regulated by the action of more than ten kinases and phosphatases, including mitogen-activated ...
Meng Zhang +2 more
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Connexin 43 impacts on mitochondrial potassium uptake [PDF]
Frontiers in Pharmacology, 2013 In cardiomyocytes, connexin 43 (Cx43) forms gap junctions and unopposed hemichannels at the plasma membrane, but the protein is also present at the inner membrane of subsarcolemmal mitochondria.
Kerstin eBoengler +4 more
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Connexin 43 confers chemoresistance through activating PI3K [PDF]
Oncogenesis, 2022 Circumventing chemoresistance is crucial for effectively treating cancer including glioblastoma, a lethal brain cancer. The gap junction protein connexin 43 (Cx43) renders glioblastoma resistant to chemotherapy; however, targeting Cx43 is difficult ...
Kevin J. Pridham +16 more
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Connexin 43 Controls the Astrocyte Immunoregulatory Phenotype [PDF]
Brain Sciences, 2018 Astrocytes are the most abundant glial cells of the central nervous system and have recently been recognized as crucial in the regulation of brain immunity.
Anne-Cécile Boulay +8 more
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Connexin 43 Hemichannels Regulate Osteoblast to Osteocyte Differentiation
Frontiers in Cell and Developmental Biology, 2022 Connexin 43 (Cx43) is the predominant connexin subtype expressed in osteocytes. Osteocytes, accounting for 90%–95% of total bone cells, function as orchestrators coordinating balanced activity between bone-resorbing osteoclasts and bone-forming ...
Rui Hua, Sumin Gu, Jean X. Jiang
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Connexin 43: An Interface Connecting Neuroinflammation to Depression
Molecules, 2023 Major depressive disorder (MDD) is a leading chronic mental illness worldwide, characterized by anhedonia, pessimism and even suicidal thoughts. Connexin 43 (Cx43), mainly distributed in astrocytes of the brain, is by far the most widely and ubiquitously
Hong Jiang +3 more
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Antidepressants impact connexin 43 channel functions in astrocytes [PDF]
Frontiers in Cellular Neuroscience, 2016 Glial cells, and in particular astrocytes, are crucial to maintain neuronal microenvironment by regulating energy metabolism, neurotransmitter uptake, gliotransmission and synaptic development.
Tiffany eJeanson +6 more
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Fluoxetin Upregulates Connexin 43 Expression in Astrocyte
Basic and Clinical Neuroscience, 2014 Introduction: Recent studies have shown that astrocytes play major roles in normal and disease condition of the central nervous system including multiple sclerosis (MS).
Hossein Mostafavi +8 more
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Connexin 43 hemichannels and related diseases. [PDF]
Antib TherAbstract Connexin 43 (Cx43) protein forms hemichannels (connexons) and gap junctions, with hemichannels consisting of six Cx43 molecules and gap junctions formed by two hemichannels. While gap junctions are prevalent in organs like the heart and liver, hemichannels are found in specific cell types, such as astrocytes and osteocytes. They
Zhang Y, Acosta FM, Jiang JX.
europepmc +3 more sources
Function of Connexin-43 in Macrophages [PDF]
International Journal of Molecular Sciences, 2020 Recent studies have helped to increase the understanding of the function of Connexin-43 (Cx43) in macrophages (Mφ). The various roles of Cx43 in Mφs range from migration, antigen-presentation and some forms of intercellular communication to more delicate processes, such as electrochemical support in the propagation of the heartbeat, immunomodulatory ...
Daniel Rodjakovic +2 more
openaire +3 more sources