Results 21 to 30 of about 195,400 (281)
Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone. [PDF]
PLoS ONE, 2011 Emerging evidence suggests that connexin mediated gap junctional intercellular communication contributes to many aspects of bone biology including bone development, maintenance of bone homeostasis and responsiveness of bone cells to diverse extracellular
Yue Zhang +8 more
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Frontiers in Oncology, 2020 Cetuximab is a monoclonal antibody that acts as an anti-epidermal growth factor receptor (EGFR) agent. Cetuximab inhibits the phosphorylation and activation of EGFR and blocks downstream signal pathways of EGF/EGFR, including Ras-Raf-MAPK and PI3K-Akt ...
Yijia Wang +7 more
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Expression of connexin-43 in surgical resections of primary tumor and lymph node metastases of squamous cell carcinoma and adenocarcinoma of the lung: a retrospective study [PDF]
PeerJ, 2022 Background Connexins are transmembrane proteins forming gap junctions between the cells, which allow intercellular communication. Significance of gap junctions and connexins in lung carcinoma is not yet understood.
Ivana Savic +4 more
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Postępy Higieny i Medycyny Doświadczalnej, 2020 Skeleton formation and its proper functioning is possible thanks to specialized bone tissue cells: bone forming osteoblasts, bone resorbing osteoclasts and osteocytes located in bone cavities. Gap junctions are transmembrane channels connecting neighboring cell. Thanks to gap junctions it is possible for signals to be directly transmitted by cells. Gap
Anna M. Osyczka +3 more
openaire +2 more sources
Connexins: synthesis, post-translational modifications, and trafficking in health and disease [PDF]
, 2018 Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs.
Aasen, Trond +5 more
core +13 more sources
Targeting Connexin 43 in Retinal Astrocytes Promotes Neuronal Survival in Glaucomatous Injury. [PDF]
GliaMain Points Astrocytes play an important role in glaucoma. These cells express Cx43 which can form gap junctions and hemichannels. This study shows Cx43 deletion in astrocytes provides neuroprotection in glaucoma, possibly through hemichannel activation.
Batsuuri K +4 more
europepmc +2 more sources
Effects of Testosterone on the Expression of Connexin 26 and Connexin 43 in the Uterus of Rats During Early Pregnancy [PDF]
, 2020 Background/Aim: It was hypothesized that testosterone could affect the distribution and expression of connexin 26 and connexin 43 in the uterus. Thus, the effects of testosterone on these parameters in the uterus during the uterine receptivity period ...
Datu Agasi Mohd Kamal +2 more
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Connexin 43 hemichannels and related diseases. [PDF]
Antib TherAbstract Connexin 43 (Cx43) protein forms hemichannels (connexons) and gap junctions, with hemichannels consisting of six Cx43 molecules and gap junctions formed by two hemichannels. While gap junctions are prevalent in organs like the heart and liver, hemichannels are found in specific cell types, such as astrocytes and osteocytes. They
Zhang Y, Acosta FM, Jiang JX.
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In Vivo and In Vitro Expression of Connexin 43 in Human Teeth [PDF]
Connective Tissue Research, 2002 Gap junctions are composed of transmembrane proteins belonging to the connexin family. These proteins permit the exchange of mall regulatory molecules directly between cells for the control of growth, development and differentiation. Although the presence of gap junctions in teeth has been already evidenced, the involved connexins have not yet been ...
Imad About +4 more
openalex +6 more sources
Connexin 43 Hemichannels Regulate Osteoblast to Osteocyte Differentiation
Frontiers in Cell and Developmental Biology, 2022 Connexin 43 (Cx43) is the predominant connexin subtype expressed in osteocytes. Osteocytes, accounting for 90%–95% of total bone cells, function as orchestrators coordinating balanced activity between bone-resorbing osteoclasts and bone-forming ...
Rui Hua, Sumin Gu, Jean X. Jiang
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