Results 51 to 60 of about 195,400 (281)
Extracellular cysteine in connexins: Role as redox sensors [PDF]
, 2016 Indexación: Scopus.Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
Báez, D. +7 more
core +2 more sources
Medicine Science, 2023 Gap junctions play a role in intercellular communication in the epithelium, muscle and nerve tissues, and many more tissues and organs. These linking regions and the proteins forming them are called connexins (Cx).
Havva Erdem +3 more
doaj +1 more source
Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery. [PDF]
, 2018 Extracellular pH is an important physiological determinant of vascular tone that is normally maintained within 7.35-7.45. Any change outside this range leads to severe pathological repercussions.
Mohanty, Ipsita +3 more
core +2 more sources
A Central Role of Connexin 43 in Hypoxic Preconditioning [PDF]
The Journal of Neuroscience, 2008 Preconditioning is an endogenous mechanism in which a nonlethal exposure increases cellular resistance to subsequent additional severe injury. Here we show that connexin 43 (Cx43) plays a key role in protection afforded by preconditioning. Cx43 null mice were insensitive to hypoxic preconditioning, whereas wild-type littermate mice exhibited a ...
Jane H-C, Lin +12 more
openaire +3 more sources
Changes of and genes in the left ventricle of spontaneously hypertensive rat after losartan treatment [PDF]
Korean Journal of Pediatrics, 2019 Purpose Increased apoptosis was recently found in the hypertrophied left ventricle of spontaneously hypertensive rats (SHRs). Although the available evidence suggests that apoptosis can be induced in cardiac cells by various insults including pressure ...
Hyeryon Lee +2 more
doaj +1 more source
Connexin 43: Key roles in the skin
Biomedical Reports, 2017 Gap junctions are tightly packed intercellular channels that serve a common purpose of allowing the intercellular exchange of small metabolites, second messengers and electrical signals. Connexins (Cxs) are gap junction proteins. Currently, 20 and 21 members of Cxs have been characterized in mice and humans, respectively. Connexin 43 (Cx43) is the most
Xiaofeng Cui, Xiao‑Fei Zhang
openaire +4 more sources
Osteoinductivity of calcium phosphate mediated by connexin 43 [PDF]
Biomaterials, 2013 Recent reports have alluded to the osteoinductive properties of calcium phosphate, yet the cellular processes behind this are not well understood. To gain insight into the molecular mechanisms of this phenomenon, we have conducted a series of in vitro and in vivo experiments using a scaffoldless three dimensional (3D) dental pulp cell (DPC) construct ...
Thottala Jayaraman +4 more
openaire +3 more sources
Blockade of Glial Connexin 43 Hemichannels Reduces Food Intake
Cells, 2020 The metabolic syndrome, which comprises obesity and diabetes, is a major public health problem and the awareness of energy homeostasis control remains an important worldwide issue. The energy balance is finely regulated by the central nervous system (CNS)
Florent Guillebaud +10 more
doaj +1 more source
Connexins : substrates and regulators of autophagy [PDF]
, 2016 Connexins mediate intercellular communication by assembling into hexameric channel complexes that act as hemichannels and gap junction channels. Most connexins are characterized by a very rapid turn-over in a variety of cell systems.
Bultynck, Geert +4 more
core +1 more source
Silicon Nanowire Mats Enable Advanced Bioelectrical Recordings in Primary DRG Cell Cultures
Advanced Healthcare Materials, EarlyView.SiNW mat‐based MEA (NW_MEA) enables continuous intracellular recordings from neurons in primary rat DRG cell cultures, identifying C‐fiber nociceptors. Supported by an astrocyte feeder layer, SiNW mat promotes DRG neuron and glial cell growth, preserving in vivo‐like cell characteristics and allowing drug‐modulated activity monitoring.
Ivano Lucarini +12 more
wiley +1 more source