Results 61 to 70 of about 1,371,072 (142)

Regulation of connexin 43 channels by PKC-mediated phosphorylation [PDF]

, 2008
Gap-junctional channels communicate adjacent cells electrically and metabolically. They are formed by 4-transmembrane helix proteins called connexins; six connexins form a connexon (or gap-junctional hemichannel) and two of these, one from each ...
Bao, X., Lee, S. C., Reuss, L., Altenberg, G. A.   +3 more
core  

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

, 2012
<p>Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a proliferative cell phenotype significantly contributes to the development of atherosclerosis.
Columbus, L., Koval, M., Johnstone, S.R., Kroncke, B.M., Isakson, B.E., Dunn, C.A., Nakamoto, R.K., Straub, A.C., Best, A.K., Lampe, P.D., Lo, C.W., Peskova, Y., Mitchell, L.A.   +12 more
core   +1 more source

Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury.

, 2023
Background: Without aviable cure, chronic kidney disease is a global health concern. Inflammatory damagein and around the renal tubules dictates disease severity and is contributed to by multiple cell types.
Christos Chadjichristos (17752530), Jessy Renciot (17752536), Claire Hills (17159905), Elena Roger (17752533), Chelsy Cliff (17171551), Gareth Price (17165578), Panagiotis Kavvadas (17752539), Paul Squires (17167891), Safia Hadjadj (17752542)   +8 more
core   +4 more sources

Changes of and genes in the left ventricle of spontaneously hypertensive rat after losartan treatment [PDF]

Korean Journal of Pediatrics, 2019
Purpose Increased apoptosis was recently found in the hypertrophied left ventricle of spontaneously hypertensive rats (SHRs). Although the available evidence suggests that apoptosis can be induced in cardiac cells by various insults including pressure ...
Hyeryon Lee, Kwan Chang Kim, Young Mi Hong   +2 more
doaj   +1 more source

Expression of gap junctional protein, connexin 43.

, 2013
Heart tissue sections were stained for gap junctional protein, connexin 43 from all four groups using immunohistochemistry. Red color indicates connexin 43 stain and blue color indicates DAPI, a nuclear stain. Merged connexin 43 and DAPI of each group is
Hai-Quan Mao (319217), Anna Blitz (370091), Matthew Joseph (205328), Mahmood Khan (139612), Ramasamy Sakthivel (370092), Hiranmoy Das (205334), Brian D. Hoit (370094), Manjusri Das (205325), Jon C. George (370089), Vincent J. Pompili (319218), Nasreen Abdulhameed (370090), Periannan Kuppusamy (43519)   +11 more
core   +1 more source

The Modulating Role of Vitamin E Against Potassium Dichromate's Cardiotoxicity in Adult Albino Rat [PDF]

The Egyptian Journal of Histology
Introduction: One extremely hazardous inorganic chemical reagent is potassium dichromate (PD). Despite its genotoxic, immunotoxic, and carcinogenic effects, it is nevertheless frequently employed in industrial and laboratory settings.
Walaa Farag, Esraa Mohamed
doaj   +1 more source

Blockade of Glial Connexin 43 Hemichannels Reduces Food Intake

Cells, 2020
The metabolic syndrome, which comprises obesity and diabetes, is a major public health problem and the awareness of energy homeostasis control remains an important worldwide issue. The energy balance is finely regulated by the central nervous system (CNS)
Florent Guillebaud, Manon Barbot, Rym Barbouche, Jean-Michel Brézun, Kevin Poirot, Flora Vasile, Bruno Lebrun, Nathalie Rouach, Michel Dallaporta, Stéphanie Gaige, Jean-Denis Troadec   +10 more
doaj   +1 more source

Plasma exosome-derived connexin43 as a promising biomarker for melanoma patients

BMC Cancer, 2023
Background To examine the levels of exosome-derived connexin 43 (Cx43) in plasma and estimate its forecast value in patients with melanoma. Methods We measured the plasma exosome-derived Cx43 levels in the plasma of 112 melanoma patients and 50 healthy ...
Yue Shen, Ming Li, Li Liao, Suyue Gao, Yongzhen Wang   +4 more
doaj   +1 more source

Identification of the Calmodulin Binding Domain of Connexin 43 [PDF]

Journal of Biological Chemistry, 2007
Calmodulin (CaM) has been implicated in mediating the Ca(2+)-dependent regulation of gap junctions. This report identifies a CaM-binding motif comprising residues 136-158 in the intracellular loop of Cx43. A 23-mer peptide encompassing this CaM-binding motif was shown to bind Ca(2+)-CaM with 1:1 stoichiometry by using various biophysical approaches ...
Yubin, Zhou, Wei, Yang, Monica M, Lurtz, Yiming, Ye, Yun, Huang, Hsiau-Wei, Lee, Yanyi, Chen, Charles F, Louis, Jenny J, Yang   +8 more
openaire   +2 more sources

Immunofluorescence for α-smooth muscle actin and connexin 43.

, 2023
When compared to the WT group (A), the MFS group (B) showed increased staining for α-smooth muscle actin (red) in the glomerulus (white arrowhead), arteriole wall (yellow arrowhead), and myofibroblast cells (white arrows), Connexin-43 (purple) showed a ...
Dieter P. Reinhardt (15440641), Keith M. Meek (10172678), Rodrigo Barbosa de Souza (7866368), Orestes Foresto-Neto (8432751), Lygia V. Pereira (7866386), Luara Lucena Cassiano (15440638), Renan Barbosa Lemes (10469425), Philip N. Lewis (15440644), Ivan Hong Jun Koh (6156680)   +8 more
core   +1 more source