Results 51 to 60 of about 23,656 (210)

Developmentally Inspired Bioprinting of Nascent Multicellular Human Heart Tissue Through in Situ Differentiation and Morphogenesis of iPSCs

Advanced Science, EarlyView.
A developmentally inspired bioprinting approach enables the fabrication of pluripotent tissues that undergo shape‐morphing and in situ cardiac lineage specification. This method employs embedded bioprinting to deposit iPSCs within soft granular hydrogels to create pluripotent tissue constructs that undergo cell‐mediated shape morphogenesis.
Ankita Pramanick, Juhi Chakraborty, Orlaith Kennedy, Hey Wei Wong, Sogol Kianersi, Daniel Kelly, Vasileios Sergis, Abhay Pandit, Andrew C. Daly   +8 more
wiley   +1 more source

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source

Connexin 43 Upregulation in Mouse Lungs during Ovalbumin-Induced Asthma. [PDF]

PLoS ONE, 2015
Connexin (Cx)-based gap junction channels play important roles in the inflammatory response. Cx43 is involved in the pathogenesis of some lung diseases such as acute lung injury. However, the Cx43 expression in asthma is unclear. In the present study, we
Yin Yao, Qing-Xiang Zeng, Xue-Quan Deng, Guan-Nan Tang, Jie-Bo Guo, Yue-Qi Sun, Kun Ru, Alicia N Rizzo, Jian-Bo Shi, Qing-Ling Fu   +9 more
doaj   +1 more source

Celastrol‐Loaded Conductive Hydrogel Mitigates Myocardial Ischemia‐Reperfusion Injury and Restores Electrophysiological Function

Advanced Science, EarlyView.
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang, Shaojie Chen, Chengzong Li, Hongyi Cheng, Jincheng Jiao, Xiafeng Peng, Yike Zhang, Wei Sun, Feng Zhang, Chang Cui, Minglong Chen   +10 more
wiley   +1 more source

Immunohistochemical assessment of possible anticancer effect mechanisms of 2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)- 5,6,7-trichloro-1,3-tropolone in PDX models of lung cancer

Южно-Российский онкологический журнал, 2023
Purpose of the study. Evaluation of the expression of immunohistochemical tumor markers Ki-67, b-catenin, Bcl-2, P53, connexin 32 and connexin 43 when using 2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)-5,6,7-trichloro-1,3-tropolone in mice with ...
E. F. Komarova, E. A. Lukbanova, E. A. Dzhenkova, A. S. Goncharova, E. V. Zaikina, S. V. Gurova, A. V. Galina, L. K. Kurbanova, M. V. Mindar, D. V. Khodakova, M. S. Gusareva, M. S. Zinkovich   +11 more
doaj   +1 more source

Osteoinductivity of calcium phosphate mediated by connexin 43 [PDF]

Biomaterials, 2013
Recent reports have alluded to the osteoinductive properties of calcium phosphate, yet the cellular processes behind this are not well understood. To gain insight into the molecular mechanisms of this phenomenon, we have conducted a series of in vitro and in vivo experiments using a scaffoldless three dimensional (3D) dental pulp cell (DPC) construct ...
Fatima N, Syed-Picard, Thottala, Jayaraman, Raymond S K, Lam, Elia, Beniash, Charles, Sfeir   +4 more
openaire   +2 more sources

An Implantable Phototriggered Prodrug Depot Patch Enables Actively Programmable Drug Release for Post‐Myocardial Infarction Therapy

Advanced Science, EarlyView.
An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu, Kaicheng Deng, Zhang Zhang, Qirui Wang, Weijing Gao, Liyin Shen, Lei Zhang, Wenting Hu, Yang Zhu, Zhengwei Mao, Tanchen Ren   +10 more
wiley   +1 more source

The Modulating Role of Vitamin E Against Potassium Dichromate's Cardiotoxicity in Adult Albino Rat [PDF]

The Egyptian Journal of Histology
Introduction: One extremely hazardous inorganic chemical reagent is potassium dichromate (PD). Despite its genotoxic, immunotoxic, and carcinogenic effects, it is nevertheless frequently employed in industrial and laboratory settings.
Walaa Farag, Esraa Mohamed
doaj   +1 more source

Blockade of Glial Connexin 43 Hemichannels Reduces Food Intake

Cells, 2020
The metabolic syndrome, which comprises obesity and diabetes, is a major public health problem and the awareness of energy homeostasis control remains an important worldwide issue. The energy balance is finely regulated by the central nervous system (CNS)
Florent Guillebaud, Manon Barbot, Rym Barbouche, Jean-Michel Brézun, Kevin Poirot, Flora Vasile, Bruno Lebrun, Nathalie Rouach, Michel Dallaporta, Stéphanie Gaige, Jean-Denis Troadec   +10 more
doaj   +1 more source

Plasma exosome-derived connexin43 as a promising biomarker for melanoma patients

BMC Cancer, 2023
Background To examine the levels of exosome-derived connexin 43 (Cx43) in plasma and estimate its forecast value in patients with melanoma. Methods We measured the plasma exosome-derived Cx43 levels in the plasma of 112 melanoma patients and 50 healthy ...
Yue Shen, Ming Li, Li Liao, Suyue Gao, Yongzhen Wang   +4 more
doaj   +1 more source