Results 81 to 90 of about 195,400 (281)
Cues to opening mechanisms from in silico electric field excitation of cx26 hemichannel and in vitro mutagenesis studies in HeLa transfectans [PDF]
, 2018 Connexin channels play numerous essential roles in virtually every organ by mediating solute exchange between adjacent cells, or between cytoplasm and extracellular milieu.
Bruno, Francesca +7 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.In a study combining network pharmacological analysis and experimental verification, yunweiling has been shown improve functional constipation by inhibiting the PI3K‐Akt‐p53 signaling pathway and reducing the expression of TP53. Abstract Background This study investigated the impacts and mechanisms of yunweiling in the management of Functional ...
Peng Zhang +6 more
wiley +1 more source
Role of Impaired Astrocyte Gap Junction Coupling in Epileptogenesis
Cells, 2023 The gap-junction-coupled astroglial network plays a central role in the regulation of neuronal activity and synchronisation, but its involvement in the pathogenesis of neuronal diseases is not yet understood.
Peter Bedner, Christian Steinhäuser
doaj +1 more source
Foundations of Quantum Mechanics according to my teachers [PDF]
arXiv, 2020 These are author's recollections of informal discussions on foundations of quantum mechanics, which happened in his presence in 1970 ...
arxiv
An overview of the focus of the International Gap Junction Conference 2017 and Future Perspectives [PDF]
, 2018 n/
Kwak, Brenda R., Martin, Patricia E.
core +2 more sources
The Anatomical Record, EarlyView.Abstract Autonomic nerves are crucial in cardiac function and pathology. However, data on the distribution of cholinergic and noradrenergic nerves in normal and pathologic human hearts is lacking. Nonfailing donor hearts were pressure‐perfusion fixed, imaged, and dissected. Left ventricular cardiomyopathy samples were also obtained.
Peter Hanna +15 more
wiley +1 more source
Expression of Connexin 43 in Granular Cell Tumors of the Skin, Tongue and Esophagus
Dermatopathology, 2023 Background: Granular cell tumors (GCT) are rare neoplasms of Schwann cell origin occurring in the skin and in other organs. The etiopathogenesis of GCT is yet poorly understood.
Hermann Kneitz +3 more
doaj +1 more source
Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma : a preclinical F98 glioblastoma rat model study [PDF]
, 2019 Purpose Even with an optimal treatment protocol, the median survival of glioblastoma (GB) patients is only 12-15 months. Hence, there is need for novel effective therapies that improve survival outcomes.
Bonte, Ellen +11 more
core +1 more source
Insulin and Metformin are Associated With Reduced Risk of Amyotrophic Lateral Sclerosis
Chronic Diseases and Translational Medicine, EarlyView.Human insulin heterodimer (A). Human insulin heterodimer (dark blue) docked within center of Cx43 channel (B) Abstract Background Type 2 diabetes (T2D), but not type 1, protected against amyotrophic lateral sclerosis (ALS). In T2D serum insulin is normal or elevated in the early stages.
Steven Lehrer, Peter H. Rheinstein
wiley +1 more source