Results 91 to 100 of about 358,200 (372)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Didattica della storia, 2019 In a society in which access to information is direct, immediate and without filters, it is absolutely essential that, from the educational system, and more specifically from the teaching of social sciences, students are provided with the necessary tools
Sebastián Molina Puche +1 more
doaj +1 more source
‘Padres de la Patria’ and the ancestral past: commemorations of independence in nineteenth-century Spanish America [PDF]
, 2002 This article examines the civic festivals held in nineteenth-century Spanish America to commemorate independence from Spain. Through such festivals political leaders hoped, in Hobsbawm's words, ‘to inculcate certain values and norms of behaviour by ...
Earle, Rebecca
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Continuidades históricas en la conquista de América [PDF]
Revista Colombiana de Ciencias Sociales, 2016 El trabajo busca proporcionar una imagen de síntesis del proceso de la conquista de América. Se destaca el enorme cambio cultural generado desde la conquista, como las tendencias de continuidad del proceso histórico en mención.
Felipe Cárdenas Tamara
doaj
Warriors, heroes and companions: negotiating masculinity in Viking-Age England [PDF]
, 2008 Detailed analysis of the construction of gender identities has transformed our understanding of many aspects of early medieval society, yet the study of the Vikings in Britain has largely remained immune to this branch of scholarship.
Hadley, D.M.
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source