Results 71 to 80 of about 4,088,501 (365)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Performance-Based Analysis of Blockchain Scalability Metric
Tehnički Glasnik, 2021 Cryptocurrencies like Bitcoin and Ethereum, are widely known applications of blockchain technology, have drawn much attention and are largely recognized in recent years.
Jyoti Yadav, Ranjana Shevkar
doaj
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Theses on Inter-Church Relations [PDF]
, 1975 Joint Commission on Inter-Lutheran Relations (JCILR ...
core +1 more source
AB0566 CONSENSUS-BASED RECOMMENDATIONS FOR THE MANAGEMENT OF PSORIATIC ARTHRITIS IN THE KINGDOM OF SAUDI ARABIA [PDF]
, 2021 H. Alrayes +12 more
openalex +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Frontiers in GeneticsIntroductionPolygenic risk scores (PRS) have emerged as a promising tool for refining cardiovascular risk prediction, yet their real-world impact on physician decision-making remains unclear. This study aimed to evaluate how the integration of a coronary
Georgios Ntritsos +8 more
doaj +1 more source
Validation of Variant Assembly Using HAPHPIPE with Next-Generation Sequence Data from Viruses
Viruses, 2020 Next-generation sequencing (NGS) offers a powerful opportunity to identify low-abundance, intra-host viral sequence variants, yet the focus of many bioinformatic tools on consensus sequence construction has precluded a thorough analysis of intra-host ...
Keylie M. Gibson +5 more
doaj +1 more source