Results 101 to 110 of about 644,259 (331)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Topological Phenomena in the Real Periodic Sine-Gordon Theory

, 2003
The set of real finite-gap Sine-Gordon solutions corresponding to a fixed spectral curve consists of several connected components. A simple explicit description of these components obtained by the authors recently is used to study the consequences of ...
Ablowitz M. J., Cherednik I. V., Dubrovin B. A., Dubrovin B. A., Dubrovin B. A., Dubrovin B. A., Dubrovin B. A., Dubrovin B. A., Ercolani N., Ercolani N. M., Flaschka H., Grinevich P. G., Its A. R., Its A. R., Kozel V. A., Krichever I. M., McKean H. P., Natanzon S. M., Novikov S. P., Novikov S. P., Novikov S. P., Novikov S. P., Novikov S. P., P. G. Grinevich, S. P. Novikov   +24 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Diversity and Conservation Gap Analysis of the Solanaceae of Southern South America. [PDF]

Front Plant Sci, 2022
Moreira-Muñoz A, Palchetti MV, Morales-Fierro V, Duval VS, Allesch-Villalobos R, González-Orozco CE.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Management reference for nature reserve networks based on MaxEnt modeling and gap analysis: a case study of the brown–eared pheasant in China [PDF]

Animal Biodiversity and Conservation, 2016
Nature reserve designs and networks are important for wildlife and habitat conservation. Gap analyses are efficient and reliable tools for prioritizing habitat conservation efforts, especially when considering endangered species.
Li, Y., Cui, B., Qiu, X., Ding, C., Batool, I.   +4 more
doaj  

Spin Hall effect of light in photon tunneling

, 2010
We resolve the breakdown of angular momentum conservation on two-dimensional photon tunneling by considering spin Hall effect (SHE) of light. This interesting effect manifests itself as polarization-dependent transverse shifts for a classic wave packet ...
Dianyuan Fan, F. I. Fedorov, Hailu Luo, J. D. Jackson, J. W. Goodman, L. Novotny, Shuangchun Wen, Weixing Shu   +7 more
core   +1 more source

Spectral Gap Inequalities in Product Spaces with Conservation Laws

Advanced Studies in Pure Mathematics, 2019
Following an idea introduced by Carlen, Carvalho and Loss [7] we propose a general strategy to prove Poincaré inequalities in product spaces with one or more conservation laws. The method is shown to yield alternative proofs of well known results, such as the diffusive bounds for the spectral gap of generalized exclusion and zero range processes. Other
openaire   +3 more sources