Results 111 to 120 of about 644,259 (331)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Conservation practitioners’ and researchers’ needs for bridging the knowledge–action gap
Frontiers in Conservation ScienceIn the field of biodiversity conservation, there is a growing need for research to translate to real-world impacts. Currently there exists a gap between research outcomes and on the ground action, commonly referred to as the knowledge-action gap ...
Alexandra N. Sabo +4 more
doaj +1 more source
Detecting management gaps for biodiversity conservation: An integrated assessment
Journal of Environmental ManagementThe latest report on the state of nature in Europe (2013-2018) shows that biodiversity is declining at an alarming rate, with most protected species and habitats in poor condition. Despite an increasing volume of collected biodiversity information, urgent action is needed to integrate biodiversity data and knowledge to improve conservation efforts.
Mónica Lanzas +11 more
openaire +3 more sources
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Pemodelan Dinamika Gelombang Dengan Mengerjakan Persamaan Kekekalan Energi [PDF]
, 2007 . This paper presents application of energy conservation law for short wave modelling. The application is done by superimposing continuity equation that resulted from mass conservation and the equation of energy conservation.
Hutahean, S. (Syawaluddin)
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Bridging the gap between conservation delivery and economics with precision agriculture
Wildlife Society Bulletin, 2019 Agricultural landscapes are important for natural resource conservation, but present numerous obstacles associated with intensive agricultural production.
Mark D. McConnell
doaj +1 more source
Persistence in tillage decisions: Aggregate data analysis
International Soil and Water Conservation Research, 2019 The Emission Gap Report 2013 from the United Nations Environment Program showed that adopting conservation tillage such as no-till, as an alternative to conventional tillage, contributes significantly to climate change mitigation through carbon ...
Dat Q. Tran, Lyubov A. Kurkalova
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source