Results 131 to 140 of about 644,259 (331)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Understanding the conservation-genetics gap in Latin America: challenges and opportunities to integrate genetics into conservation practices

Frontiers in Genetics
Introduction: Integrating genetic data into conservation management decisions is a challenging task that requires strong partnerships between researchers and managers.
Constanza Napolitano, Constanza Napolitano, Constanza Napolitano, Cristhian Clavijo, Viviana Rojas-Bonzi, Viviana Rojas-Bonzi, Carolina I. Miño, José F. González-Maya, Nadia Bou, Alan Giraldo, Angela Martino, Cristina Yumi Miyaki, Luis F. Aguirre, Andrea Cosacov, Yoamel Milián-García, Laura Prosdocimi, O. Eric Ramírez-Bravo, Luis Antonio Tovar, Ximena Velez-Zuazo, Mercedes Barrios, Bernal Herrera-Fernández, María G. Montiel-Villalobos, María A. Oliveira-Miranda, Monique Pool, Alonso Santos-Murgas, Maria Claudia Segovia-Salcedo, Felipe Cecchi, Armando J. Dans, Nelanie Dilchand, Sergio M. Q. Lima, María Caridad Novas, Karla Pelz-Serrano, Nina Pougy, Iris Rodríguez, Liesbeth van der Meer, Galo Zapata-Ríos   +35 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Response to Climate Change and GAP Analysis of Thuja koraiensis Nakai

Plants
Due to global warming and increased human activity, the wild population of Thuja koraiensis Nakai (T. koraiensis) has dropped, placing it in danger. An understanding of the response of T.
Xiuhua Yang, Xiaoyu Li, Jiaqi Cui, Ruiqi Liu, Jitong Li, Chengjun Yang   +5 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Assessment gaps and biases in knowledge of conservation status of fishes [PDF]

, 2020
Imanol Miqueleiz, Monika Böhm, Arturo H. Ariño, Rafael Miranda   +3 more
openalex   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Kreat.Kreat...Taktak-Toktok: Between the Gaps of Conservation

, 2023
Auger, Catherine
openalex   +1 more source