Results 101 to 110 of about 90,973 (227)

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

The SALCOR framework: A transformative approach to employee well-being

SA Journal of Industrial Psychology
Orientation: The well-being of employees is essential for the sustainability of an organisation; however, current models frequently neglect the significant connection between individual resources and organisational culture.
Nthabeleng Mdhluli, Sonja Grobler
doaj   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source

Resource effects of COVID‐induced work‐from home: A qualitative study of parental and non‐parental white collar workers in Germany

European Management Review, EarlyView.
Abstract Germany is a corporate environment that is sceptical towards digitalization and work‐from‐home, and in which it is customary to separate professional and personal spheres of life. The COVID‐19 pandemic, and ensuing government‐mandated shutdowns, changed all that by inducing extensive work‐from‐home conditions for most of the white collared ...
Jasmin Mahadevan, Sven Metzler, Jule Amelie Vögele, Raphael Diehm   +3 more
wiley   +1 more source

Kitaev's Z_d-Codes Threshold Estimates

, 2013
We study the quantum error correction threshold of Kitaev's toric code over the group Z_d subject to a generalized bit-flip noise. This problem requires novel decoding techniques, and for this purpose we generalize the renormalization group method we ...
Duclos-Cianci, Guillaume, Poulin, David
core   +1 more source

Exercise‐related microRNAs in Caenorhabditis elegans regulate calcium homeostasis and mitochondrial dynamics: Conserved pathways, divergent microRNAs

The FEBS Journal, EarlyView.
Exercise‐related microRNAs cel‐miR‐249‐3p and cel‐miR‐77‐5p in C. elegans regulate lifespan, fitness, mitochondrial morphology and membrane potential. Although lacking direct mammalian orthologs, H2O2‐induced microRNAs mmu‐miR‐181a‐5p and mmu‐miR‐378a‐3p regulate myogenesis, autophagy, mitochondrial content and respiration in murine myoblasts ...
Qin Xia, Jiwang Tang, José C. Casas‐Martinez, Penglin Li, Maria Borja‐Gonzalez, Leo R Quinlan, Katarzyna Goljanek‐Whysall, Brian McDonagh   +7 more
wiley   +1 more source

Uncovering Gender and Temporal Dynamics: Career Resources Impacting Career Success

Administrative Sciences
(1) Background/Purpose: Talent management research has typically focused on early-career entrants or high-potential employees, leaving mid-career professionals underexplored despite their pivotal role in organisational continuity and leadership pipelines.
Wika Malkowska, Vicki Elsey, Laura Longstaff, John Arnold   +3 more
doaj   +1 more source

Navigating Quality in Lean Times: Sustaining Laboratory Standards Amidst Budget Constraints

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Healthcare systems in wealthy countries are facing rising costs due to ageing populations and the prevalence of chronic illnesses, leading to constrained budgets. Pathology services, essential for accurate diagnosis and treatment, have merged to cope with these financial pressures.
Gordon Sinclair
wiley   +1 more source

Job Stress, Ego Depletion, and Turnover Intention: The Buffering Role of Islamic Spiritual Well-Being in the Hospitality Industry

Jurnal Manajemen Universitas Bung Hatta
High levels of work stress and employee turnover are classic problems in the hospitality industry that have serious implications for organizational sustainability.
Jovinda Percillia Ma’rifatul Umairoh, Fatmah Bagis, Hengky Widhiandono, Azmi Fitriati   +3 more
doaj   +1 more source

Muslim mothers’ intersecting tensions in combining breastfeeding and employment: A systematic review and research agenda

International Journal of Management Reviews, EarlyView.
Abstract The intersection of gender, time and marginalization in organizations is evident in the challenges faced by employed mothers, particularly those who are breastfeeding. These challenges are amplified for Muslim mothers, who must navigate intersecting social identities within these structures shaped by dominant masculine norms.
Feranaaz Farista, Ameeta Jaga
wiley   +1 more source