Results 41 to 50 of about 1,090 (138)

Harnessing Cellular Feeling: Epigenetic to Mechanical Memory as a Framework for Stem Cell Manufacturing

Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1481-1490, June 2026.
ABSTRACT Stem cell‐based therapies hold transformative potential for regenerative medicine, yet their progress is constrained by persistent variability in manufacturing and clinical performance. Conventional frameworks such as Quality by Design (QbD), though effective for drugs and biologics, struggle to accommodate the dynamic nature of living cell ...
Mee‐Hae Kim, Masahiro Kino‐oka
wiley   +1 more source

Genetically Programmed Control of Overflow Metabolism

Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1624-1633, June 2026.
ABSTRACT Overflow metabolism is a highly undesirable phenomenon that occurs in virtually all cell factories. Although several schemes have been applied to avoid overflow metabolism, this problem remains far from being solved. In this study, a genetic sensor for detecting overflow metabolism was designed, and its substrate specificity and reversibility ...
Lærke M. Jensen, Andriy Glushchuk, Thilde P. Hjorth, Alvaro R. Lara   +3 more
wiley   +1 more source

Addressing Small Data Challenges in Biopharmaceutical Development and Manufacturing: A Mini Review of Multi‐Fidelity Techniques

Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1465-1480, June 2026.
ABSTRACT The growing demand for biopharmaceutical products reflects their effectiveness in medical treatments. However, developing new biopharmaceuticals remains a major bottleneck, often taking up to a decade before market approval. Machine learning (ML) models have the potential to accelerate this process, but their success depends on access to large
Mohammad Golzarijalal, Uwe Aickelin, Ellen Otte   +2 more
wiley   +1 more source

Robust Constrained Partial Least Squares: A Robust Integrated Algorithm for Multivariate Regression in the Presence of Outliers, Interfering Analytes, and Structured External Influences

Journal of Chemometrics, Volume 40, Issue 6, June 2026.
ABSTRACT Partial least squares (PLS) regression is widely used for multivariate calibration in high‐dimensional and collinear settings. However, classical PLS relies on least squares optimization and is therefore sensitive to anomalous observations, leverage points, and structured spectral interferences.
Puneet Mishra
wiley   +1 more source

Recent Progress on Enzyme Immobilization: Materials, Strategies, and Applications

Food Bioengineering, Volume 5, Issue 2, Page 220-243, June 2026.
Enzyme immobilization technology has undergone substantial evolution driven by advances in materials science. This review systematically examines the recent advances in enzyme immobilization since 2024, with a focused analysis of five major categories of enzyme carriers including covalent organic framework, metal‐organic frameworks, polymers, carbon ...
Shuran Wang, Ruoke Li, Yixuan Xie, Hanya Zhang, Xiaoyu Huang, Siwei Chen, Weixin Xu, Yueling Liu   +7 more
wiley   +1 more source

Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley   +1 more source

Tumor‐Resident Mast Cells Facilitated Breast Cancer Progression via Activating Type I Interferon Pathway

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Breast cancer cell‐derived stem cell factor (SCF) activates c‐KIT‐mediated MAPK/ERK signaling in mast cells, inducing IFNB1 production. Mast cell‐derived IFNB1 then engages the IFNAR1‐STAT1 axis in breast cancer cells, activating the Type I interferon pathway to promote tumor stemness and progression.
Siqin Li, Juchuanli Tu, Ruoyi Ding, Xueyan He, Xian Zhang, Mengxue Dong, Fengkai Li, Wen Yi, Yuwei Tao, Wei Ma, Zhijun Dai, Zhenhua Chen, Yuan Wang, Xiongbin Lu, Jian Liu, Suling Liu, Jiahui Xu   +16 more
wiley   +1 more source

Engineering natural isolates of Saccharomyces cerevisiae for consolidated bioprocessing of cellulosic feedstocks. [PDF]

Appl Microbiol Biotechnol, 2023
Minnaar L, den Haan R.
europepmc   +1 more source

Modeling of Consolidated Bioprocessing for Bioproduction—A Comprehensive Review

With the rising global population and increasing energy demands, sustainable bioproducts such as bioethanol offer essential alternatives to fossil fuels. Unlike first-generation bioethanol derived from food crops like corn, second-generation bioethanol is produced from lignocellulosic (LC) biomass, a non-food resource that addresses sustainability ...
Mark Korang Yeboah, Dirk Söffker
openaire   +1 more source

Physicochemical Properties and Mechanisms of Oil‐In‐Water Emulsion Formation and Stabilization by Yeast Protein Ingredients From Saccharomyces cerevisiae and Candida utilis

Sustainable Food Proteins, Volume 4, Issue 2, June 2026.
Emulsion formation is associated with the soluble phase, while the presence of yeast cells enhances stability through a steric mechanism, with a protein‐to‐oil ratio greater than 1:10 required to prevent oil droplet coalescence. ABSTRACT This study explored the nutrient composition, protein profile, physicochemical and emulsifying properties of ...
Luca Amagliani, Nicola Cesario Angelino, Claudine Bovay, Charlotte Gancel, Fikrey Andetsion, Michael Affolter, Carine Morgenegg, Biljana Bogicevic, Giulia Marchesini   +8 more
wiley   +1 more source