Results 71 to 80 of about 1,301 (164)

Grey-box modeling framework for consolidated bioprocessing systems: an endpoint-guided approach

Bioresources and Bioprocessing
Consolidated bioprocessing (CBP) combines enzyme production, biomass hydrolysis, and fermentation within a single process, but its modeling remains difficult because of biological nonlinearities, feedstock heterogeneity, and limited time-resolved ...
Mark Korang Yeboah, Dirk Söffker
doaj   +1 more source

Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy

iMetaMed, EarlyView.
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia, Guiling Fu, Xiaoyue Ding, Wen Yang, Ruijie Bai, Yawei Cai, Jing xuan Zhang, Yanxia Wei, Conghui Han, Yi‐Zhou Gao, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Developing Organisms for Consolidated Bioprocessing of Biomass to Ethanol

, 2011
Lignocellulosic biomass is an abundant, renewable feedstock for sustainable production of biofuels and chemicals. The main technological barrier that impedes widespread utilization of this resource for production of fuels and other commodity products is the lack of low-cost technologies to overcome the recalcitrance of lignocellulose.
Willem H. van Zyl, Riaan den, Daniel C. la Grange   +2 more
openaire   +2 more sources

Consolidated bioprocessing of transgenic switchgrass by an engineered and evolved Clostridium thermocellum strain. [PDF]

Biotechnol Biofuels, 2014
Switchgrass is an abundant and dedicated bioenergy feedstock, however its inherent recalcitrance is one of the economic hurdles for producing biofuels. The downregulation of the caffeic acid O-methyl transferase (COMT) gene in the lignin pathway of switchgrass reduced lignin content and S/G ratio, and the transgenic lines showed improved fermentation ...
Yee KL, Rodriguez M, Thompson OA, Fu C, Wang ZY, Davison BH, Mielenz JR.   +6 more
europepmc   +4 more sources

Integrated one‐pot CRISPR‐Cas detection: Addressing strategies and future prospects

Interdisciplinary Medicine, EarlyView.
Integrated one‐pot CRISPR‐Cas detection significantly simplifies workflows, reduces cross‐contamination risks, and shortens turnaround times, making it highly suitable for point‐of‐care testing (POCT) and resource‐limited settings. Key challenges include system compatibility issues between Cas proteins and isothermal amplification, limited multiplexing
Jian Zhou, Xuemei Ren, Yingjie Ren, Ruiping Wu, Ruiman Geng, Le Chen, Zhuo Li   +6 more
wiley   +1 more source

Surfactant Enhanced Bioremediation of Saline Diesel Contaminated Water by a Novel Bacterial Halophilic Consortium

Journal of Surfactants and Detergents, EarlyView.
ABSTRACT The use of microorganisms is an evolving method for the degradation of hydrocarbon contaminants. In this aim, halophilic hydrocarbon degrading bacteria were isolated from oil contaminated soil in Tunisia. A lipopeptide biosurfactant produced by Bacillus subtilis SPB1 was tested to increase diesel biodegradation along with co‐inoculation with ...
Inès Mnif, Dhouha Ghribi
wiley   +1 more source

Cellulase secretion by engineered Pseudomonas putida enables growth on cellulose oligomers

Applied Microbiology and Biotechnology
Pseudomonas putida is an attractive synthetic biology platform organism for chemical synthesis from low-grade feedstocks due to its high tolerance to chemical solvents and lignin-derived small molecules that are often inhibitory to other ...
Madeline R. Smith, Kaylee Moffitt, William Holdsworth, Carlos H. Luna-Flores, Mansi Goyal, Alex Beliaev, Robert E. Speight, James B. Behrendorff   +7 more
doaj   +1 more source

Engineering redox-balanced ethanol production in the cellulolytic and extremely thermophilic bacterium, Caldicellulosiruptor bescii

Metabolic Engineering Communications, 2018
Caldicellulosiruptor bescii is an extremely thermophilic cellulolytic bacterium with great potential for consolidated bioprocessing of renewable plant biomass.
Amanda M. Williams-Rhaesa, Gabriel M. Rubinstein, Israel M. Scott, Gina L. Lipscomb, Farris L. Poole, II, Robert M. Kelly, Michael W.W. Adams   +6 more
doaj   +1 more source

Multimodal artificial intelligence in medical biotechnology: Integrating genomics, imaging, and clinical data for precision therapeutics

Precision Medical Sciences, EarlyView.
Overview of multimodal artificial intelligence (AI) for precision therapeutics. Diverse biomedical data modalities, including multi‐omics, medical imaging, digital pathology, electronic health records, wearable‐device data, and molecular information, are integrated through multimodal AI frameworks incorporating fusion strategies, foundation models ...
Gedion Mengistu Dejen
wiley   +1 more source

Osmotic Remodeling of Extracellular Vesicles for Precision Nanomedicine

Small, EarlyView.
Hypotonic lysis in bidistilled water is used to remodel B lymphocyte–derived extracellular vesicles into cargo‐depleted, structurally preserved nanovesicles. The process reduces intraluminal proteins and nucleic acids, reshapes membrane composition, and enhances tumor‐cell uptake in vitro, while allowing proof‐of‐concept reloading with exogenous agents,
Francesca Susa, Lorenzo Arnaboldi, Veronica De Giorgis, Marco Ghirimoldi, Elettra Barberis, Marco Brucale, Francesco Valle, Mario Malerba, Marta Vallino, Angelo Musicò, Roberto Frigerio, Alessandro Gori, Vera Mugoni, Claudia Voena, Roberto Pisano, Fabrizio Pirri, Silvia Arpicco, Marcello Manfredi, Tania Limongi   +18 more
wiley   +1 more source