Results 61 to 70 of about 19,178 (296)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
A Class of Weingarten Surfaces in Euclidean 3-Space
Abstract and Applied Analysis, 2013 The class of biconservative surfaces in Euclidean 3-space 𝔼3 are defined in (Caddeo et al., 2012) by the equation A(grad H)=-H grad H for the mean curvature function H and the Weingarten operator A.
Yu Fu, Lan Li
doaj +1 more source
Fluidic shaping and in-situ measurement of liquid lenses in microgravity
npj Microgravity, 2023 In the absence of gravity, surface tension dominates over the behavior of liquids. While this often poses a challenge in adapting Earth-based technologies to space, it can also provide an opportunity for novel technologies that utilize its advantages. In
Omer Luria +11 more
doaj +1 more source
Compact Constant Mean Curvature Surfaces with Low Genus [PDF]
Experimental Mathematics, 1997 We describe numerical experiments that suggest the existence of certain new compact surfaces of constant mean curvature. They come in three dihedrally symmetric families, with genus ranging from 3 to 5, 7 to 10, and 3 to 9, respectively; there are further surfaces with the symmetry of the Platonic polyhedra and genera 6, 12, and 30.
Große-Brauckmann, Karsten +1 more
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
On the late phase of relaxation of two-dimensional fluids: turbulence of unitons
New Journal of Physics, 2017 The two-dimensional ideal fluid and the plasma confined by a strong magnetic field exhibit an intrinsic tendency to organization due to the inverse spectral cascade. In the asymptotic states reached at relaxation the turbulence has vanished and there are
F Spineanu, M Vlad
doaj +1 more source
Graphs with constant mean curvature in the 3-hyperbolic space
Anais da Academia Brasileira de Ciências, 2002 In this work we will deal with disc type surfaces of constant mean curvature in the three dimensional hyperbolic space which are given as graphs of smooth functions over planar domains.
PEDRO A. HINOJOSA
doaj +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Rotationally invariant constant mean curvature surfaces in homogeneous 3-manifolds [PDF]
, 2009 We classify constant mean curvature surfaces invariant by a 1-parameter group of isometries in the Berger spheres and in the special linear group Sl(2,R).
Torralbo, Francisco, Francisco Torralbo
core +1 more source