Results 51 to 60 of about 4,460,960 (252)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Conversor CC-CC trifásico ZVS PWM de três níveis [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica.Esta tese propõe uma topologia de conversor CC-CC trifásico de três níveis, modulado por largura de pulso e com comutação ...
Agostini Junior, Eloi
core  

Optimal design of high frequency high efficiency and high‐power density DC–DC power module based on GaN

IET Power Electronics, 2023
This paper develops a railway power module with wide range voltage (dc 60—dc 160 V) input and constant voltage output (24 V/10 A) . The power module adopts a two‐stage topology structure to realize voltage conversion.
Guowang Liu, Honglin Ouyang, Muxuan Xiao
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Maximum Efficiency Tracking for Dynamic WPT System Based on Optimal Input Voltage Matching

IEEE Access, 2020
Wireless power transfer (WPT) technology has drawn much attention due to its advantages such as safety, convenience, and non-contact. For some movable devices such as intelligent inspection robot, the constant output voltage is very important to ensure ...
Hao He, Songcen Wang, Youwei Liu, Cheng Jiang, Xiaokang Wu, Bin Wei, Bingwei Jiang   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Constant Voltage Output in Two-Chamber Microbial Fuel Cell Under Fuzzy PID Control

International Journal of Electrochemical Science, 2013
Microbial fuel cells (MFCs) have been receiving more and more attention in simultaneous treatment of wastewater and energy recovery. Past research has been mainly in experiments. Modelling and controlling are new subjects emerging recently.
Minxiu Yan, Liping Fan
doaj   +1 more source