Results 71 to 80 of about 471,152 (307)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A Constant Voltage/Current CPT System With Lightweight Characteristics for the Unmanned Aerial Vehicle

IEEE Access
The large weight of the unmanned aerial vehicle (UAV) could cause a decrease in endurance mileage, while poor anti-offset performance could extend charging time and may even damage onboard equipment.
Yufang Chang, Xiaoke Zhang, Chao Ma, Wencong Huang, Huaicheng Yan   +4 more
doaj   +1 more source

Inverterless high-power interior permanent-magnet automotive alternator [PDF]

, 2003
This paper describes a high-power brushless interior permanent-magnet (PM) automotive alternator which does not use an inverter. The “inverterless” alternator is designed with a high back electromotive force voltage and high reactance, and acts as a ...
Ertugrul, N., Soong, W.
core   +2 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Design and Implementation of a Wireless Power Transfer System Using LCL Coupling Network with Inherent Constant-Current and Constant-Voltage Output for Battery Charging

Energies
The constant current followed by constant voltage (CC-CV) charging method is commonly employed for battery charging, effectively extending battery life and reducing charging time.
Pengqiang Nie, Song Xu, Zhenlin Wang, Seiji Hashimoto, Linfeng Sun, Takahiro Kawaguchi   +5 more
doaj   +1 more source

Optimal Constant DC Link Voltage Operation of aWave Energy Converter

Energies, 2013
This article proposes a simple and reliable damping strategy for wave powerfarm operation of small-scale point-absorber converters. The strategy is based on passiverectification onto a constant DC-link, making it very suitable for grid integration of the
Mats Leijon, Venugopalan Kurupath, Rickard Ekström   +2 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

WPT system for constant current and constant voltage charging based on switched resonant frequency

Wireless Power Transfer
This paper designs and implements an innovative WPT system that possesses the capability to seamlessly switch between constant current (CC) and constant voltage (CV) outputs, thereby fully satisfying the various charging requirements of batteries for ...
Zhen Guo, Zhaodong Li, Haitao Yu, Hailong Zhang, Jiqiu Nai, Shuang Chen, Ranran Liu, Min Zhang   +7 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source