Results 71 to 80 of about 10,462,770 (299)

Benjamin Constant lecteur du Contrat social

, 2003
International audienceIn 1806, in the manuscript of "Principles of politics applicable to all governments", Benjamin Constant proposes a critique of Jean-Jacques Rousseau’s "Social contract".
Paulet-Grandguillot, Emmanuelle
core   +5 more sources

A microfluidic study on the influence of naturally fractured porous media on the phase behavior of condensate gas depletion

Natural Gas Industry B
There are limited quantitative studies on condensate gas using microfluidics under high-pressure and high-temperature conditions. This study employed microfluidics chips based on real porous media structures to conduct constant volume depletion ...
Kuiqian Ma, Shuoshi Wang, Lei Zhang, Haojun Wu, Jintao Wu, Ping Guo, Lei Huang, Qixuan Zhang, Limiao Wang   +8 more
doaj   +1 more source

P6.04 PULSE VOLUME HOMEOSTASIS AS A HYPOTHESIZED PRINCIPLE OF ARTERIAL DESIGN

Artery Research, 2013
The increase of arterial volume during the systole (‘pulse volume’) is essential for buffering the pulsatile ventricular output. Objectives: Deriving some mechanical properties of arteries by assuming pulse volume homeostasis.
B. Gavish
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Constant, Sismondi et la Pologne

, 2021
Constant et Sismondi ont été profondément marqués par le démembrement progressif et la chute de la Pologne, survenue en 1795, sur laquelle des commentaires parsèment leurs œuvres.
Bertholet, Auguste
core   +1 more source

Stable degeneration of families of klt singularities with constant local volume

Forum of Mathematics, Sigma
For a klt singularity, C. Xu and Z. Zhuang [33] proved the associated graded algebra of a minimizing valuation of the normalized volume function is finitely generated, finishing the proof of the stable degeneration conjecture proposed by C. Li and C. Xu.
Zhiyuan Chen
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Simulation studies of combustion in a constant-mass variable-volume combustion chamber [PDF]

FME Transactions, 2018
A numerical simulation code was used to conduct a systematic study of the effects of fuel-air equivalence ratios in the range 0.7 ≤ φ ≤ 1.4 and compression ratio, rc = 8.0 on key operating parameters, such as pressure, rate of change of pressure, '/dt ...
Anetor Lucky, Osakue Edward E.
doaj  

A numerical investigation of constant-volume non-Boussinesq density currents [PDF]

, 2010
The time-dependent behaviour of non-Boussinesq high-Reynolds-number density currents of density ρc, released from a lock of height h₀ and length x₀ into a ambient of height H and density ρₐ, is considered. We use two dimensional Navier-Stokes simulations
Ungarish, Marius, Balachandar, Sivaramakrishnan, Bonometti, Thomas   +2 more
core  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source