Results 181 to 190 of about 127,679 (266)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Investigating the Relationship Between Body Constitution as Defined Under Traditional Chinese Medicine and Vertigo in Women in Taiwan. [PDF]

J Nurs Res
Tang PL, Chou HC, Lin ML, Wu TF, Pan TC.
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Traditional Chinese medicine constitution characteristics and influencing factors for acute mountain sickness susceptibility in rapidly ascending high-altitude populations: a cross-sectional survey. [PDF]

J Health Popul Nutr
Long M, Liu B, Tang C, Liu J, Jing C, Zhang Y, Li H, Lu J, Zheng W, Yang J, Chen Y, Gan X, Pan Z, Wang C, Wang L, Zhu P, Shan M, Cheng M, Wang Y, Xu Z.   +19 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Association between traditional Chinese medicine constitution and depression in adolescents: A cross-sectional study. [PDF]

Medicine (Baltimore)
Hao Y, Yin J, Huang Z, Zhang Y, Liu Y, Zhang J, Fang X, Lan Z, Luo B, Lu M, Zhang Z, Chen J.   +11 more
europepmc   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

The mediating and moderating roles of physical sub-health in the relationship between family functioning and mental health problems among Chinese adolescents. [PDF]

BMC Public Health
Zhang Y, Cai X, Jiang G, Xu W, Ran Y, Han D, Wen H, Liu Y.   +7 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Building science and subjectivity from flesh. Towards a reconceptualization of neurophenomenology as a contribution to interdisciplinary health research. [PDF]

Med Health Care Philos
Wiltsche HA, Zeiler K.
europepmc   +1 more source