Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Die Constitution des Ornithins und des Lysins. Zugleich ein Beitrag zur Chemie der Eiweissfäulniss. [PDF]
, 1900 Alexander Ellinger
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Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
The American Constitution as It Protects Private Rights
, 1924 Thomas Reed Powell +1 more
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Ueber die Constitution der Phenochinone, Thiophenochinone und Chinhydrone. Ein Versuch zur einheitlichen Erklärung der Additionsvorgänge beim Chinon [PDF]
, 1904 Theodor Posner
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Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
LXVIII. Further analytical experiments relative to the constitution of the prussic, of the ferruretted chyazic, and of the sulphuretted chyazic acids; and to that of their salts; together with the application of the atomic theory to the analyses of those bodies [PDF]
Robert Porrett
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Ueber die Constitution der Indolgruppe im Eiweiss. III. Mittheilung: Oxydation des Tryptophans zu β‐ Indolaldehyd [PDF]
, 1906 Alexander Ellinger
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Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source
Journal of Traditional Chinese Medical SciencesObjective: To identify key factors influencing cognitive function in the elderly, including traditional Chinese medicine (TCM) constitutional classification, and to rank their relative importance.
Houqin Li +6 more
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