Results 61 to 70 of about 723,570 (245)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A constitutive model with damage for high temperature superalloys [PDF]
A unified constitutive model is searched for that is applicable for high temperature superalloys used in modern gas turbines. Two unified inelastic state variable constitutive models were evaluated for use with the damage parameter proposed by Kachanov ...
Sherwood, J. A., Stouffer, D. C.
core +1 more source
A Dislocation based Constitutive Model for Warm Forming of Aluminum Sheet [PDF]
, 2008 The formability of aluminum sheet can be improved considerably by increasing the temperature.\ud At elevated temperatures, the mechanical response of the material becomes strain rate dependent.\ud To accurately simulate warm forming of aluminum sheet, a ...
Boogaard, A.H. van den +2 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Explicit finite element implementation of a shape memory alloy constitutive model and associated analyses [PDF]
, 2017 Shape memory alloys (SMA) represent an important class of smart metallic materials employed in various innovative applications thanks to their unique thermomechanical behavior.
Auricchio, F. +5 more
core
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Anisotropic constitutive modeling for nickel base single crystal superalloy Rene N4 at 982 C [PDF]
A back stress/drag stress constitutive model based on a crystallographic approach to model single crystal anisotropy is presented. Experimental results demonstrated the need for the back stress variable in the inelastic flow equations.
Alden, D. +3 more
core +1 more source