Results 41 to 50 of about 38,046 (312)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Some remarks on duality and optimality of a class of constrained convex quadratic minimization problems [PDF]

open access: yesYugoslav Journal of Operations Research, 2017
In this paper the duality and optimality of a class of constrained convex quadratic optimization problems have been studied. Furthermore, the global optimality condition of a class of interval quadratic minimization problems has also been ...
Roy Sudipta   +2 more
doaj   +1 more source

Constrained Next-to-Minimal Supersymmetric Standard Model [PDF]

open access: yesPhysical Review Letters, 2008
We consider the fully constrained version of the next-to-minimal supersymmetric extension of the standard model (cNMSSM) in which a singlet Higgs superfield is added to the two doublets that are present in the minimal extension (MSSM). Assuming universal boundary conditions at a high scale for the soft supersymmetry-breaking gaugino, sfermion and Higgs
Djouadi, A.   +2 more
openaire   +3 more sources

Proposed shunt rounding technique for large-scale security constrained loss minimization

open access: yes, 2010
The official published version can be obtained from the link below - Copyright @ 2010 IEEE.Optimal reactive power flow applications often model large numbers of discrete shunt devices as continuous variables, which are rounded to their nearest discrete ...
Irving, MR   +4 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Minimal constrained superfields and the Fayet–Iliopoulos model [PDF]

open access: yesThe European Physical Journal C, 2018
We show how the necessary constraints to project out all the components of a chiral superfield except for some scalar degrees of freedom originate from simple operators in the microscopic theory. This is in particular useful in constructing the simplest models of a goldstone boson/inflaton; or extracting the Standard Model Higgs doublet from a ...
Benakli, Karim   +2 more
openaire   +4 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Cell geometry determines symmetric and asymmetric division plane selection in Arabidopsis early embryos. [PDF]

open access: yesPLoS Computational Biology, 2019
Plant tissue architecture and organ morphogenesis rely on the proper orientation of cell divisions. Previous attempts to predict division planes from cell geometry in plants mostly focused on 2D symmetric divisions.
Julien Moukhtar   +7 more
doaj   +1 more source

Constrained Texture Synthesis via Energy Minimization [PDF]

open access: yesIEEE Transactions on Visualization and Computer Graphics, 2007
This paper describes CMS (constrained minimization synthesis), a fast, robust texture synthesis algorithm that creates output textures while satisfying constraints. We show that constrained texture synthesis can be posed in a principled way as an energy minimization problem that requires balancing two measures of quality: constraint satisfaction and ...
Ganesh Ramanarayanan, Kavita Bala
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

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