Results 61 to 70 of about 231,170 (284)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A bound-constrained formulation for complex solution phase minimization [PDF]

Geoscientific Model Development
Prediction of mineral phase assemblages is essential to better understand the dynamics of the solid Earth, such as metamorphic processes, magmatism and the formation of mineral ore deposits.
N. Riel, N. Riel, B. J. P. Kaus, B. J. P. Kaus, B. J. P. Kaus, A. de Montserrat, E. Moulas, E. Moulas, E. Moulas, E. C. R. Green, H. Dominguez   +10 more
doaj   +1 more source

Optimal mistuning for enhanced aeroelastic stability of transonic fans [PDF]

, 1983
An inverse design procedure was developed for the design of a mistuned rotor. The design requirements are that the stability margin of the eigenvalues of the aeroelastic system be greater than or equal to some minimum stability margin, and that the mass ...
Crawley, E. F., Hall, K. C.
core   +1 more source

High resolution image reconstruction with constrained, total-variation minimization

, 2011
This work is concerned with applying iterative image reconstruction, based on constrained total-variation minimization, to low-intensity X-ray CT systems that have a high sampling rate.
Chartrand, Rick, Duchin, Yuval, Pan, Xiaochuan, Sidky, Emil Y., Ullberg, Christer   +4 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Analysis of local minima for constrained minimization problems [PDF]

, 2014
We consider vectorial problems in the calculus of variations with an additional pointwise constraint. Our admissible mappings ${\bf n}:\mathbb{R}^k\rightarrow \mathbb{R}^d$ satisfy ${\bf n}(x)\in M$, where $M$ is a manifold embedded in Euclidean space ...
Bedford, S. J.
core  

Delivery Time Reduction for Order-Constrained Applications using Binary Network Codes

, 2016
Consider a radio access network wherein a base-station is required to deliver a set of order-constrained messages to a set of users over independent erasure channels.
Douik, Ahmed, Karim, Mohammad S., Sadeghi, Parastoo, Sorour, Sameh   +3 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Constrained Eigenvalue Minimization of Incomplete Pairwise Comparison Matrices by Nelder-Mead Algorithm

Algorithms, 2021
Pairwise comparison matrices play a prominent role in multiple-criteria decision-making, particularly in the analytic hierarchy process (AHP). Another form of preference modeling, called an incomplete pairwise comparison matrix, is considered when one or
Hailemariam Abebe Tekile, Michele Fedrizzi, Matteo Brunelli   +2 more
doaj   +1 more source

Robust Sum MSE Optimization for Downlink Multiuser MIMO Systems with Arbitrary Power Constraint: Generalized Duality Approach

, 2012
This paper considers linear minimum meansquare- error (MMSE) transceiver design problems for downlink multiuser multiple-input multiple-output (MIMO) systems where imperfect channel state information is available at the base station (BS) and mobile ...
Bogale, Tadilo Endeshaw, Vandendorpe, Luc   +1 more
core   +1 more source