Results 71 to 80 of about 231,170 (284)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Existence and Stability of Standing Waves for Nonlinear Fractional Schrödinger Equations with Hartree Type and Power Type Nonlinearities

open access: yesAdvances in Mathematical Physics, 2016
We consider the standing wave solutions for nonlinear fractional Schrödinger equations with focusing Hartree type and power type nonlinearities. We first establish the constrained minimization problem via applying variational method.
Na Zhang, Jie Xin
doaj   +1 more source

Detection of Insect Damage in Green Coffee Beans Using VIS-NIR Hyperspectral Imaging

open access: yesRemote Sensing, 2020
The defective beans of coffee are categorized into black beans, fermented beans, moldy beans, insect damaged beans, parchment beans, and broken beans, and insect damaged beans are the most frequently seen type.
Shih-Yu Chen   +3 more
doaj   +1 more source

PARROT: Prediction of enzyme abundances using protein-constrained metabolic models.

open access: yesPLoS Computational Biology, 2023
Protein allocation determines the activity of cellular pathways and affects growth across all organisms. Therefore, different experimental and machine learning approaches have been developed to quantify and predict protein abundance and how they are ...
Mauricio Alexander de Moura Ferreira   +2 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Kohn-Sham equations for nanowires with direct current

open access: yes, 2003
The paper describes the derivation of the Kohn-Sham equations for a nanowire with direct current. A value of the electron current enters the problem as an input via a subsidiary condition imposed by pointwise Lagrange multiplier.
D. S. Kosov, Grossmann F.
core   +1 more source

Generalized nesterov’s algorithm for constrained minimization problems on closed convex sets

open access: yesTạp chí Khoa học và Công nghệ, 2023
In this paper, we propose a generalized Nesterov algorithm for the constrained optimization problems on a closed convex set. We prove the convergence as well as the convergence rate of the proposed algorithm.
Pham Quy Muoi   +2 more
doaj   +1 more source

A Primal-Dual Algorithmic Framework for Constrained Convex Minimization [PDF]

open access: yes, 2014
We present a primal-dual algorithmic framework to obtain approximate solutions to a prototypical constrained convex optimization problem, and rigorously characterize how common structural assumptions affect the numerical efficiency.
Cevher, Volkan, Tran-Dinh, Quoc
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

An Augmented Penalization Algorithm for the Equality Constrained Minimization Problem

open access: yesTrends in Computational and Applied Mathematics, 2002
In this contribution an iterative method for solving the nonlinear minimization problem with equality constraints is presented. The method is based on the sequential minimization of the differentiable penalization function known as augmented Lagrangian ...
M.C. MACIEL, G.N. SOTTOSANTO
doaj   +1 more source

Home - About - Disclaimer - Privacy