Results 81 to 90 of about 231,170 (284)

Investigation on Self-Scaling of Mixed Interior-Exterior Method for Non-Linear Optimization [PDF]

Al-Rafidain Journal of Computer Sciences and Mathematics, 2005
In this paper, we have investigated self-scaling sequential unconstrained minimization techniques  (SUMT). Our new modified version on CG-method and QN- method shows that it is too effective when compared with other established  algorithms to solve ...
Ghada Al-Naemi
doaj   +1 more source

On a continuation approach in Tikhonov regularization and its application in piecewise-constant parameter identification

, 2013
We present a new approach to convexification of the Tikhonov regularization using a continuation method strategy. We embed the original minimization problem into a one-parameter family of minimization problems.
Melicher, Valdemar, Vrabel, Vladimir
core   +1 more source

Efficient Constrained Regret Minimization

, 2012
Online learning constitutes a mathematical and compelling framework to analyze sequential decision making problems in adversarial environments. The learner repeatedly chooses an action, the environment responds with an outcome, and then the learner receives a reward for the played action. The goal of the learner is to maximize his total reward. However,
Mahdavi, Mehrdad, Yang, Tianbao, Jin, Rong   +2 more
openaire   +2 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Constrained minimization for monotonic reconstruction [PDF]

13th Computational Fluid Dynamics Conference, 1997
The authors present several innovations in a method for monotonic reconstructions. It is based on the application of constrained minimization techniques for the imposition of monotonicity on a reconstruction. In addition, they present extensions of several classical TVD limiters to a genuinely multidimensional setting.
William Rider, Douglas Kothe, William Rider, Douglas Kothe   +3 more
openaire   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Optimality conditions for interval-valued univex programming

Journal of Inequalities and Applications, 2019
We introduce concepts of interval-valued univex mappings, consider optimization conditions for interval-valued univex functions for the constrained interval-valued minimization problem, and show examples for the illustration purposes.
Lifeng Li, Jianke Zhang, Chang Zhou
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Solving Generalized Mixed Equilibria, Variational Inequalities, and Constrained Convex Minimization

Abstract and Applied Analysis, 2014
We propose implicit and explicit iterative algorithms for finding a common element of the set of solutions of the minimization problem for a convex and continuously Fréchet differentiable functional, the set of solutions of a finite family of generalized
A. E. Al-Mazrooei, A. Latif, J. C. Yao
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source