Results 51 to 60 of about 229,971 (268)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A bound-constrained formulation for complex solution phase minimization [PDF]

Geoscientific Model Development
Prediction of mineral phase assemblages is essential to better understand the dynamics of the solid Earth, such as metamorphic processes, magmatism and the formation of mineral ore deposits.
N. Riel, N. Riel, B. J. P. Kaus, B. J. P. Kaus, B. J. P. Kaus, A. de Montserrat, E. Moulas, E. Moulas, E. Moulas, E. C. R. Green, H. Dominguez   +10 more
doaj   +1 more source

Cell geometry determines symmetric and asymmetric division plane selection in Arabidopsis early embryos. [PDF]

PLoS Computational Biology, 2019
Plant tissue architecture and organ morphogenesis rely on the proper orientation of cell divisions. Previous attempts to predict division planes from cell geometry in plants mostly focused on 2D symmetric divisions.
Julien Moukhtar, Alain Trubuil, Katia Belcram, David Legland, Zhor Khadir, Aurélie Urbain, Jean-Christophe Palauqui, Philippe Andrey   +7 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Compressive Pattern Matching on Multispectral Data

, 2014
We introduce a new constrained minimization problem that performs template and pattern detection on a multispectral image in a compressive sensing context. We use an original minimization problem from Guo and Osher that uses $L_1$ minimization techniques
Blanc-Talon, J., Carré, P., Helbert, D., Rousseau, S.   +3 more
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Existence and Stability of Standing Waves for Nonlinear Fractional Schrödinger Equations with Hartree Type and Power Type Nonlinearities

Advances in Mathematical Physics, 2016
We consider the standing wave solutions for nonlinear fractional Schrödinger equations with focusing Hartree type and power type nonlinearities. We first establish the constrained minimization problem via applying variational method.
Na Zhang, Jie Xin
doaj   +1 more source

Optimality conditions for interval-valued univex programming

Journal of Inequalities and Applications, 2019
We introduce concepts of interval-valued univex mappings, consider optimization conditions for interval-valued univex functions for the constrained interval-valued minimization problem, and show examples for the illustration purposes.
Lifeng Li, Jianke Zhang, Chang Zhou
doaj   +1 more source

Detection of Insect Damage in Green Coffee Beans Using VIS-NIR Hyperspectral Imaging

Remote Sensing, 2020
The defective beans of coffee are categorized into black beans, fermented beans, moldy beans, insect damaged beans, parchment beans, and broken beans, and insect damaged beans are the most frequently seen type.
Shih-Yu Chen, Chuan-Yu Chang, Cheng-Syue Ou, Chou-Tien Lien   +3 more
doaj   +1 more source