Results 171 to 180 of about 860,607 (233)

Methodological guidelines for the characterization of polysaccharide helical structures

Food Biomacromolecules, EarlyView.
Abstract Polysaccharide chain conformation is a critical determinant of their physicochemical and biological properties; however, reliable identification remains a significant challenge due to the inconsistent structural evidence yielded by conventional analytical techniques.
Yixuan Wu, Shudan Luo, Meifang Zhong, Yinle Cai, Yinshu Li, Xu Lu   +5 more
wiley   +1 more source

Single‐Cell RNA Sequencing and Spatial Multiomics Unveil Microglia–Mural Interactions Underlying Notoginsenoside R1 Against Ischemic Stroke

iMetaMed, EarlyView.
Integrated scRNA‐seq and spatial multiomics provide single‐cell and spatial insights into the neuroprotective effects of NGR1, a clinically validated bioactive compound from Panax notoginseng. NGR1 was associated with a shift in microglial transcriptional states away from ischemia‐associated pro‐inflammatory Adam8hi microglia and toward the protective ...
Qikun Zhao, Wenbo Guo, Yanrong Zheng, Guoqian Cui, Bingjie Wan, Shuhui Deng, Hudong Bao, Xiao Tu, Shengshuang Chen, Jie Liao, Xiaohui Fan   +10 more
wiley   +1 more source

Multi‐Parametric Phase‐Cycled Balanced Steady‐State Free Precession Brain Tissue Characterization in Relapsing‐Remitting Multiple Sclerosis

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Time‐efficient phase‐cycled balanced steady‐state free precession (pc‐bSSFP) imaging is a novel microstructure‐ and myelin‐sensitive approach for multi‐parametric brain tissue characterization not yet evaluated in demyelinating diseases such as multiple sclerosis (MS).
Florian Birk, Benjamin Bender, Hamzeh Tesh, Anagha Deshmane, Maris M. Fabian, Markus C. Kowarik, Tobias Lindig, Ulrike Ernemann, Klaus Scheffler, Rahel Heule   +9 more
wiley   +1 more source

Perspectives of High‐Resolution Mass Spectrometry in Soil Science

Journal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Soil biogeochemical research requires specific, sensitive, and accurate methods to identify and quantify organic molecules in order to trace biochemical processes and assess element cycling in complex, heterogenous systems. High‐resolution mass spectrometry (HRMS) has evolved into a transformative tool for unraveling the complex chemical ...
Bruno Glaser, Tobias Bromm, Klaus Kaiser, Arthur Gross, Carsten Simon, Snežana Maletić, Ines Mulder, Oliver J. Lechtenfeld, Sören Thiele‐Bruhn, Ivy Notterpek, Callum Banfield, Michaela A. Dippold   +11 more
wiley   +1 more source

Calibration‐Free Single‐Frame Super‐Resolution Fluorescence Microscopy

Laser &Photonics Reviews, EarlyView.
A deep learning framework reconstructs super‐resolved fluorescence images from a single dense camera frame, without any prior calibration or knowledge of the microscope. Trained solely on synthetic data, it generalizes across imaging setups and conditions.
Anežka Dostálová, Dominik Vašinka, Robert Stárek, Miroslav Ježek   +3 more
wiley   +1 more source

Robust Fiber Orientation Distribution Function Estimation Using Deep Constrained Spherical Deconvolution for Diffusion MRI

Diffusion-weighted magnetic resonance imaging (DW-MRI) is a critical imaging method for capturing and modeling tissue microarchitecture at a millimeter scale.
Asad, Zuhayr, Ramadass, Karthik, Newlin, Nancy, Landman, Bennett A., Rheault, Francois, Huo, Yuankai, nath, Vishwesh, Deng, Ruining, Cui, Can, Schilling, Kurt, Yao, Tianyuan, Shafer, Andrea, Cai, Leon Y, Resnick, Susan   +13 more
core  

Cortical Cholinergic Pathway Degeneration Reflects Cognitive Impairment and Dementia in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Cognitive impairment is a prevalent and debilitating feature of Parkinson's disease (PD). Increasing evidence from postmortem and in vivo positron emission tomography imaging studies supports cholinergic dysfunction in PD. There is, however, little evidence regarding the influence of the structural integrity of cortical cholinergic ...
Nicola M. Slater, Daniel J. Myall, Reza Shoorangiz, Wassilios G. Meissner, Ian J. Kirk, Ross J. Keenan, Rebecca M. Lee, Kyla‐Louise Horne, Michael R. MacAskill, Campbell J. Le Heron, Toni L. Pitcher, Tim J. Anderson, Tracy R. Melzer, John C. Dalrymple‐Alford   +13 more
wiley   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Influence of THF as Internal‐Donor on Ziegler‐Natta Polyethylene Catalysts

Macromolecular Reaction Engineering, EarlyView.
Ziegler–Natta catalysts remain widely applied due to robustness, handling ease, and cost‐effectiveness. To support further optimization, we examine how internal donors such as tetrahydrofuran influence catalyst performance and polymer characteristics.
Alexander Mottl, Sarah Brunner, Patrik Schneider, Fabian Hofmann, Moritz Pischulti, Dario Pindirc, Clemens Schwarzinger, Christian Paulik   +7 more
wiley   +1 more source

The b‐Value Dependence for Higher‐Degree Spherical Harmonic Powers of the Diffusion MRI Signal Follows Stick Model Predictions in White Matter

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To compare the dependence on b‐value of the spherical harmonic powers for the diffusion MRI signal in white matter to theoretical predictions from the stick model of water diffusion within axons. Methods Diffusion MRI data were acquired at 3 T in three healthy adults with 10 b‐value shells (b = 1000–10 000 s/mm2) and 64 directions per ...
Hunter G. Moss, Jens H. Jensen, Andreana Benitez   +2 more
wiley   +1 more source