Results 41 to 50 of about 29,551 (265)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
CONSTRAINT PROGRAMMING AND UNIVERSITY TIMETABLING
South African Journal of Industrial Engineering, 2012 <p>ENGLISH ABSTRACT: The technology of Constraint Programming is rapidly becoming a popular alternative for solving large-scale industry problems.
G.W. Groves, W. Van Wijck
doaj
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Basic Techniques for Creating an Efficient CSP Solver [PDF]
Scientific Annals of Computer Science, 2007 Many computationally difficult problems from areas like planning and scheduling are easily modelled as constraint satisfaction problems (CSP). In order to have an uniform practical approach of these, a new programming paradigm emerged in the form of ...
C. Frăsinaru
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Труды Института системного программирования РАН, 2018 Object-oriented constraint-based programming (OOCP) combines two orthogonal, but complementary programming paradigms, namely: object-oriented programming (OOP) and constraint logic programming (CLP).
V. A. Semenov +3 more
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A Hybrid Method for the Modelling and Optimisation of Constrained Search Problems
Foundations of Management, 2014 The paper presents a concept and the outline of the implementation of a hybrid approach to modelling and solving constrained problems. Two environments of mathematical programming (in particular, integer programming) and declarative programming (in ...
Sitek Pawel, Wikarek Jaroslaw
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
A hybrid approach to protein folding problem integrating constraint programming with local search
BMC Bioinformatics, 2010 Background The protein folding problem remains one of the most challenging open problems in computational biology. Simplified models in terms of lattice structure and energy function have been proposed to ease the computational hardness of this ...
Steinhöfel Kathleen, Ullah Abu
doaj +1 more source