Results 61 to 70 of about 50,089 (313)

On Testing Constraint Programs [PDF]

open access: yes, 2010
The success of several constraint-based modeling languages such as OPL, ZINC, or COMET, appeals for better software engineering practices, particularly in the testing phase. This paper introduces a testing framework enabling automated test case generation for constraint programming. We propose a general framework of constraint program development which
Lazaar, Nadjib   +2 more
openaire   +4 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Object-oriented constraint-based programming: a new paradigm using declarative data modeling languages

open access: yesТруды Института системного программирования РАН, 2018
Object-oriented constraint-based programming (OOCP) combines two orthogonal, but complementary programming paradigms, namely: object-oriented programming (OOP) and constraint logic programming (CLP).
V. A. Semenov   +3 more
doaj  

A hybrid approach to protein folding problem integrating constraint programming with local search

open access: yesBMC Bioinformatics, 2010
Background The protein folding problem remains one of the most challenging open problems in computational biology. Simplified models in terms of lattice structure and energy function have been proposed to ease the computational hardness of this ...
Steinhöfel Kathleen, Ullah Abu
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The inductive constraint programming loop

open access: yes, 2016
Constraint programming is used for a variety of real-world optimization problems, such as planning, scheduling and resource allocation problems. At the same time, one continuously gathers vast amounts of data about these problems.
O'Sullivan, Barry   +32 more
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

On constraint qualifications in mathematical programming

open access: yesДоклады Белорусского государственного университета информатики и радиоэлектроники, 2019
The article is devoted to the condition of R-regularity (Error Bound Property) in problems of mathematical programming. This condition plays an important role in analyzing the convergence of numerical optimization algorithms and it is a fairly general ...
L. I. Minchenko, S. I. Sirotko
doaj  

Open constraint programming

open access: yesArtificial Intelligence, 2005
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Boi Faltings, Santiago Macho-Gonzalez
openaire   +1 more source

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