Results 91 to 100 of about 13,464 (314)

Simultaneous Adrenal and Cardiac G-Protein–Coupled Receptor-Gβγ Inhibition Halts Heart Failure Progression

, 2014
ObjectivesThe authors propose simultaneous inhibition of Gβγ signaling in the heart and the adrenal gland as a novel therapeutic approach for heart failure (HF).BackgroundElevated sympathetic nervous system activity is a salient characteristic of HF ...
Smrcka, Alan V., Travers, Joshua G., Wegman, Katherine M., Moalem, Jacob, Hammes, Stephen R., Kamal, Fadia A., Mickelsen, Deanne M., Blaxall, Burns C.   +7 more
core   +1 more source

Strategic Design of Soft Actuators in Translational Medical Robotics for Human‐Centered Healthcare

Advanced Robotics Research, EarlyView.
Soft robotics enables biocompatible, compliant medical devices, but clinical translation requires design‐driven engineering beyond materials. This perspective reviews implantable, surgical, and wearable systems by actuation mechanism, highlighting how optimized architectures and integration improve mechanical interfacing, adaptability, and durability ...
Ho Jun Jin, Jimin Kim, Inho Kim, Bong Hoon Kim   +3 more
wiley   +1 more source

A Low‐Cost, Handheld Optical Stiffness Sensor for Minimally Invasive Surgery

Advanced Robotics Research, EarlyView.
A novel handheld stiffness sensor is presented for real‐time tissue stiffness characterization. By simultaneously sensing contact force and tissue deformation, the device enables accurate stiffness quantification without requiring precise manual control. This approach offers a promising solution for intraoperative tumor detection and minimally invasive
Qianyu Ma, Ruxiang Jiang, Kaspar Althoefer, Nicolas Herzig, Hareesh Godaba   +4 more
wiley   +1 more source

N, S Co‐Doped Carbon Quantum Dots‐Riboflavin Composite Photosensitizers for Enhanced Iontophoresis‐Assisted Corneal Cross‐Linking

Advanced Science, EarlyView.
This study explores the use of N, S co‐doped carbon quantum dots (NS‐CQDs) as carriers for riboflavin, creating NS‐CQDs‐RF composite photosensitizers. These composites improve riboflavin absorption, enhance ROS generation efficiency, and preserve corneal epithelium integrity.
Tinghong Xu, Yong Liu, Wenjing Zhang, Qiuruo Jiang, Yi Jin, Liangzheng Lin, Lumeng Wang, Zhanhao Gu, Mimi Lin, Shihao Chen   +9 more
wiley   +1 more source

Endovascular treatment of fulminant idiopathic intracranial hypertension associated with intracranial venous sinus stenosis: one case report

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To report one case of fulminant idiopathic intracranial hypertension (FIIH) associated with intracranial venous sinus stenosis, and explore its clinical characteristics, diagnostic strategies, and the feasibility and efficacy of endovascular ...
LIU Shi-min, CAO Xian-min, WU Ling-feng, XIANG Zheng-bing, WEN An, CAO Wen-feng   +5 more
doaj   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Cervical esophagogastric anastomosis with invagination after esophagectomy Anastomose esofagogástrica cervical com invaginação após esofagectomia

Acta Cirúrgica Brasileira, 2012
PURPOSE: To evaluate the incidence of fistula and stenosis of the cervical esophagogastric anastomosis with invagination of the proximal esophageal stump into the stomach after subtotal esophagectomy.
Alexandre Cruz Henriques, Felipe Emanuel Fuhro, Carlos Alberto Godinho, Andre Luiz Lopes Cardoso Campos, Jaques Waisberg   +4 more
doaj   +1 more source

Image_1_Inhibiting Receptor of Advanced Glycation End Products Attenuates Pressure Overload-Induced Cardiac Dysfunction by Preventing Excessive Autophagy.JPEG

, 2018
The receptor for advanced glycation end products (RAGE) is involved in heart failure (HF) by mediating diverse pathologic processes, including the promotion of inflammation and autophagy.
Cui Yan (3820771), Zhongqi Yang (703895), Jiajia Wang (157207), Zheng Zhou (152309), Yusheng Huang (5780705), Birong Liang (5780702), Wenbin Gao (825538), Lingjun Wang (4516606), Zhaorui Wen (5780708), Yang Chen (9737), Lu Zhang (50563), Lu Lu (392), Shaoxiang Xian (4516615)   +12 more
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Morphometric analysis of intimal thickening secondary to stent placement in pig carotid arteries Análise morfométrica do espessamento intimal secundário ao implante de stent em artérias carótidas de suínos

Acta Cirúrgica Brasileira, 2008
OBJECTIVE: To evaluate intimal thickening secondary to stent placement or to insertion of the delivery system without stent placement in pig carotid arteries. METHODS: Stents were placed in the right common carotid arteries of 7 pigs, and 7 other control
Márcio Bastiani Pasa, Adamastor Humberto Pereira, Cyro Castro Júnior   +2 more
doaj   +1 more source