Results 21 to 30 of about 19,523 (194)

Rabbit models of heart disease. [PDF]

, 2008
Human heart disease is a major cause of death and disability. A variety of animal models of cardiac disease have been developed to better understand the etiology, cellular and molecular mechanisms of cardiac dysfunction and novel therapeutic strategies ...
Bers, Donald M, Pogwizd, Steven M
core  

Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal [PDF]

, 2011
Activation of tissue mast cells (MCs) and their abnormal growth and accumulation in various organs are typically found in primary MC disorders also referred to as mastocytosis.
Akin C, Akin C, Akin C, Alberto Orfao, Alvarez-Twose I, Arock M, Arredondo AR, Austen KF, Awad JA, Bodemer C, Boguslaw Nedoszytko, Bonadonna P, Butterfield JH, Castells MC, Cem Akin, Chin KW, Costa JJ, Daley T, Dean D. Metcalfe, Di Lorenzo G, Donker ML, Finkelman FD, Galli SJ, Garcia-Montero AC, Golden DB, González de Olano D, Hans-Peter Horny, Hogan AD, Horny HP, Johansson SG, Jordan JH, Joseph H. Butterfield, Karin Hartmann, Karl Sotlar, Knut Brockow, Lawrence B. Schwartz, Lieberman P, Luis Escribano, Maintz L, Mariana Castells, Massimo Triggiani, Melody C. Carter, Metcalfe DD, Metcalfe DD, Metcalfe DD, Michel Arock, Morel AM, Murphy S, Nedoszytko B, Peavy RD, Peter Valent, Philip Lieberman, Rivera J, Rudolf Valenta, Ruëff F, Samorapoompichit P, Sampson HA, Schwartz LB, Schwartz LB, Schwartz LB, Schwelberger HG, Serafin WE, Sonneck K, Sperr WR, Vadas P, Valent P, Valent P, Valent P, Valent P, Valent P, van der Donk EM, van Toorenenbergen AW, Webb LM, Wolfgang R. Sperr   +73 more
core   +1 more source

Flow‐Induced Vascular Remodeling on‐Chip: Implications for Anti‐VEGF Therapy

Advanced Functional Materials, EarlyView.
Flow‐induced vascular remodeling plays a critical role in network stabilization and function. Using a vasculature‐on‐chip system, this study reveals how physiological VEGF levels and flow affect vascular remodeling and provides insights into tumor vessel normalization.
Fatemeh Mirzapour‐Shafiyi, Elias Huber, Leonie Karr, Johnny Tong, Andreas Richard Bausch, Friedrich Christian Simmel, Karen Alim   +6 more
wiley   +1 more source

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog. [PDF]

, 2019
People heterozygous for an activating mutation in protein kinase G1 (PRKG1, p.Arg177Gln) develop thoracic aortic aneurysms and dissections (TAAD) as young adults.
Boss, Gerry R, Casteel, Darren E, Dalton, Nancy D, Gu, Yusu, Kalyanaraman, Hema, Lee, Seunghoe, Makino, Ayako, Milewicz, Dianna M, Patel, Hemal H, Peterson, Kirk L, Pilz, Renate B, Schilling, Jan M, Schwaerzer, Gerburg K, Wahwah, Nisreen, Zhang, Qian, Zhuang, Shunhui   +15 more
core   +1 more source

Long-term exposure to methylmercury and psychiatric symptoms in residents of Minamata, Japan [PDF]

, 2011
Introduction: It is well-known that prenatal or postnatal exposure to methylmercury can produce neurological signs in adults and children, exemplified by a case of large-scale poisoning in Minamata, Japan, in the 1950s.
Bradley, Clarkson, Doi, Ekino, Fujiki, George, Grandjean, Harada, Harada, Harada, Harada, Harada, Hastie, Inoue, Kitamura, Masazumi Harada, Matsushima, Minamata Disease Research Group, Ninomiya, Ninomiya, Nishigaki, Sachiko Inoue, Selvin, Soshi Takao, Takashi Yorifuji, Tatetsu, Tomiyasu, Toshihide Tsuda, Tsuda, U.S.EPA., Wigle, Yorifuji, Yorifuji   +32 more
core   +1 more source

Ensemble Model-based Clinical Decision Support System for Inherited Retinal Diseases in Pediatric Age [PDF]

, 2023
In recent years, advancements in healthcare technology have paved the way for innovative approaches to clinical decision support systems (CDSS), especially in the context of inherited retinal diseases (IRD) affecting the pediatric population.
J.Nikhila, K. Smita, Reddy, G.Sanjana
core   +2 more sources

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice [PDF]

, 2017
Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive ...
Birnbaumer, Lutz, Harada, Eri, Ishikawa, Tatsuya, Kitajima, Naoyuki, Kumagai, Yoshito, Nishida, Motohiro, Nishimura, Akiyuki, Numaga Tomita, Takuro, Oda, Sayaka, Shimauchi, Tsukasa, Tomizaki, Takashi   +10 more
core   +1 more source

Organoid‐Like Neurovascular Spheroids Promote the Recovery of Hypoxic‐Ischemic Skin Flaps Through the Activation of Autophagy

Advanced Healthcare Materials, EarlyView.
Highly sprouting organoid‐like neurovascular spheroids (NVUs) are developed, featuring cell‐loaded poly‐3‐hydroxybutyrate 4‐hydroxybutyrate(P34HB) porous microsphere cores embedded within Gelatin Methacryloyl. NVUs formed complex vascular plexuses and secreted extracellular matrix in vitro, simulating autologous nerves and blood interaction.
Junjin Jie, Jingyi Ju, Zhenxing Wang, Jun Chen, Lin‐Ping Wu, Jiaming Sun   +5 more
wiley   +1 more source

Designing for Degradation: Transient Devices Enabled by (Nano)Cellulose

Advanced Materials, EarlyView.
Recent progress in transient devices enabled by (nano)cellulosic materials is reviewed. Transiency mechanisms, advantages of nanocelluloses, and a suite of applications are discussed. A circular thinking approach coupled with life cycle assessment is applied to critically revisit the potential, advantages, and challenges of nanocellulose‐enabled ...
Lucas J. Andrew, Erlantz Lizundia, Mark J. MacLachlan   +2 more
wiley   +1 more source