Results 121 to 130 of about 2,613 (292)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Study About Buckling Phenomenon in Perforated Thin Steel Plates Employing Computational Modeling and Constructal Design Method

Latin American Journal of Solids and Structures
Perforated steel thin plates are commonly used in structural engineering. Due to their geometric characteristics, these panels can suffer the undesired buckling phenomenon.
Daniel Helbig, Caio Cesar Cardoso da Silva, Mauro de Vasconcellos Real, Elizaldo Domingues dos Santos, Liércio André Isoldi, Luiz Alberto Oliveira Rocha   +5 more
doaj   +1 more source

Otimização de design do duto ramificado em forma de T com escoamento de fluido newtoniano e paredes impermeáveis [PDF]

, 2018
Este artigo apresenta os resultados de escoamentos em dutos em forma de “T”. O problema consiste em encontrar as resistências ao escoamento em estruturas tridimensionais (3D) cujos sistemas têm diferentes relações homotética entre tamanhos (diâmetros e ...
Miguel, A. F., Pepe, V. R., Rocha, L. A. O., Zinani, F. S. F.   +3 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Design and fabrication of a heat exchanger for portable solar water distiller system [PDF]

, 2016
Heat exchanger H.X.s is the equipment used to transfer the thermal energy between two or more fluids at varying temperatures. The nature of this paper is an experimental study of the optimum design for shell and tube heat exchanger as a condenser with ...
Abduhamed, A. J., Adam, Nor Mariah, Hairuddin, Abdul Aziz, Kareem, H. K.   +3 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Locomotion rhythm makes power and speed. [PDF]

Sci Rep, 2023
Bejan A, Gunes U, Almahmoud H.
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Numerical and Geometric Analysis of Side-Wall Inclination Angle Effects on Longitudinal Hat-Stiffeners in Steel Plates

Applied Mechanics
Thin steel plates with stiffeners are widely employed in several branches of engineering, combining mechanical strength with low weight and serving as both structural and cladding components.
Guilherme Garcia Madsen, Mariana Alvarenga Alves, Luiz Alberto Oliveira Rocha, Elizaldo Domingues dos Santos, William Ramires Almeida, Liércio André Isoldi   +5 more
doaj   +1 more source

Modelling the behaviour of thermal energy harvesting devices with phase-change materials. [PDF]

Sci Rep, 2021
Kulish V, Hyhlík T, Sláma P.
europepmc   +1 more source