Results 121 to 130 of about 407,747 (298)

Idea Networking: Constructing a Pragmatic Conceptual Frame for Action Research Interventions

, 2014
© 2013, Springer Science+Business Media New York. Action research interventions require use of some form of conceptual frame to guide and evaluate the intervention.
Metcalfe, M, Hassanli, N., Hassanli, N, Metcalfe, M., Najmeh Hassanli, Mike Metcalfe   +5 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Heterotic string field theory with manifest spacetime supersymmetry

Journal of High Energy Physics
Using the hybrid formalism with manifest N = 1 d = 4 spacetime supersymmetry, we construct the quadratic term in the heterotic superstring field theory action.
Nathan Berkovits, Ulisses M. Portugal
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Covariant quantization of the superstring in AdS3 × S3 × T4 with mixed flux

Journal of High Energy Physics
A quantizable and manifestly PSU(1, 1|2) × PSU(1, 1|2)-invariant action for the superstring in AdS3 × S3 × T4 with mixed NS-NS and R-R self-dual three-form flux is constructed, which is the analogue of the AdS5 × S5 pure spinor action for AdS3 × S3.
Cassiano A. Daniel
doaj   +1 more source

Constructed action and Constructed dialogues als Diskursphänomene von Gebärdensprachen: Eine vergleichende Untersuchung von Rekonstruktionen in der Deutschen Gebärdensprache und im Deutschen und die sich daraus ergebenden Implikationen

, 2006
Die vorliegende Diplomarbeit widmet sich den gebärdensprachlichen Diskursphänomenen constructed action und constructed dialogue. Dazu werden diese beiden Begriffe erläutert und in ihrem Wesen und ihren Funktionen beschrieben.
Paesler, Katja
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

On the variational principle for a system of ordinary differential equations

Современная математика: Фундаментальные направления
Necessary and sufficient conditions for the direct representability of one system of ordinary differential equations in the form of Lagrange-Ostrogradsky equations are obtained and the corresponding variational principle (the Hamilton-Ostrogradsky action)
Svetlana A. Budochkina, Thi Huyen Luu
doaj   +1 more source