Results 101 to 110 of about 4,674,321 (263)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A prosodic approach of constructed action in Belgian French

Constructed action is a communicative strategy whereby speakers use their bodies and voices to depict referents, actions, and thoughts. By using a corpus-based study, this research analyses the use of constructed action and constructed dialogue in the ...
Cousin, Hadrien
core   +2 more sources

Keynote address: The action learning, action research experiences of professionals

, 2019
This keynote relates the experiences of professional educational-practitioners, which contribute to the legacy of action learners, action researchers, and others concerned with transforming social change for the flourishing of humanity.
Whitehead, Jack
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A School’s Own Adaptation of Action Learning: From a Traditional Action Learning Project, to a Whole School Action Learning Project, to a Professional Learning Culture.

, 2017
Action Learning finds its basis in experimental learning theory. For the staff at Western Public school Action Learning and experimental learning underpin their success of the use of Action Learning within their school.
Mehorter, Bronwyn Ruth
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

On the variational principle for a system of ordinary differential equations

Современная математика: Фундаментальные направления
Necessary and sufficient conditions for the direct representability of one system of ordinary differential equations in the form of Lagrange-Ostrogradsky equations are obtained and the corresponding variational principle (the Hamilton-Ostrogradsky action)
Svetlana A. Budochkina, Thi Huyen Luu
doaj   +1 more source

Improving Indigenous Women’s Wellness Through Action Research

, 2013
This paper describes an action research project undertaken with Indigenous women in the highly urbanised area of north Brisbane. The project was a collaborative effort to move beyond the alarming statistics of Indigenous women’s poor health status.
Walker, Melissa, Anderson, Debra, Fredericks, Bronwyn   +2 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

ON GROUP ACTION AND COHOMOLOGY THEORY

Academic Science Journal
   In this work, The concept of group action and cohomology group are considered with a lots of details. Group action is a concept in abstract algebra describe how group acts on a set.
Seena Jabar Khamees
doaj   +1 more source