Results 81 to 90 of about 2,187,228 (292)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

KPZ Analysis for $W_3$ Gravity

, 1992
Starting from the covariant action for $W_3$ gravity, we discuss the BRST quantization of $W_3$ gravity. Taking the chiral gauge the BRST charge has a natural interpretation in terms of the quantum Drinfeld--Sokolov reduction for $Sl(3,\re)$.
Bergshoeff, Bershadsky, Bershadsky, Bouwknegt, de Boer, de Boer, Drinfeld, Drinfeld, Fateev, Feigin, Fradkin, Frenkel, Henneaux, Horvath, Hull, Itoh, Jacob Goeree, Jan de Boer, Knizhnik, Kuramoto, Matsuo, Ooguri, Polyakov, Polyakov, Polyakov, Polyakov, Pope, Schoutens, Schoutens, Verlinde   +29 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A covariantisation of M5-brane action in dual formulation

Journal of High Energy Physics, 2018
We construct a manifestly diffeomorphic M5-brane action in dual formulation coupled to an eleven-dimensional supergravity target space. The covariantisation is carried out by using (generalised) PST technique with 5 auxiliary scalar fields, which are ...
Sheng-Lan Ko, Pichet Vanichchapongjaroen
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Reflexivity and Narratives in Action Research: A Discursive Approach

Forum: Qualitative Social Research, 2003
The paper offers an analysis of how narratives may be reflexively used at different stages of the research process as a tool to access the interpretative frameworks that actors use to construct their accounts of events and to make sense of their action ...
Monica Colombo
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Low-energy effective action in 5D,N=2 supersymmetric gauge theory

Nuclear Physics B, 2019
We construct N=2 supersymmetric low-energy effective action of 5D,N=2 supersymmetric Yang–Mills (SYM) theory in 5D,N=1 harmonic superspace. It is obtained as a hypermultiplet completion of the leading Wln⁡W-term in the N=1 SYM low-energy effective action
I.L. Buchbinder, E.A. Ivanov, I.B. Samsonov   +2 more
doaj   +1 more source

First results from a parametrized Fixed-Point QCD action

, 2001
We have constructed a new fermion action which is an approximation to the (chirally symmetric) Fixed-Point action, containing the full Clifford algebra with couplings inside a hypercube and paths built from renormalization group inspired fat links.
DeGrand, DeGrand, F. Niedermayer, Gattringer, Ginsparg, Hasenfratz, Hasenfratz, Hasenfratz, K. Holland, Kaplan, Lüscher, Narayanan, Narayanan, Niedermayer, Niedermayer, P. Hasenfratz, S. Hauswirth, Shamir, T. Jörg   +18 more
core   +1 more source