Results 91 to 100 of about 2,012,270 (353)

The IT performance evaluation in the construction industry [PDF]

, 2000
To date there has been limited published work in the construction management and engineering literature that has provided empirical evidence to demonstrate that IT can improve organizational performance.
Irani, Z, Li, H, Love, P E D
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Carbon emission modeling of excavation and non-excavation techniques in overall repair of drainage pipelines

Systems and Soft Computing
Due to the rising levels of CO2 emissions in China, the calculation of carbon emissions and the evaluation of the environmental advantages associated with pipeline maintenance have become significant concerns.
Xiao Yu, Xiaodong Hu, Wen Xie, Aichen Pan, Xinke Li, Huijuan Wang   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Pine wood nematode disease area identification based on multi-temporal multi-source remote sensing images and BIT model

Geocarto International
Pine wood nematode (PWN) disease is a severe contagious disease in forests which endangers the health of forests, as it can rapidly kill trees. The detection of regions impacted by this disease plays a crucial role in forest management, remediation ...
Degao Wang, Zhangyu Sun, Xinxia Huang, Mingzhong Liu, Qingqing Zheng, Huailiang Zhang, Guanghe Zhang   +6 more
doaj   +1 more source

Performance evaluation of bolter miner cutting head by using multicriteria decision-making approaches

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2017
A bolter miner is a new type of mining machinery with cutting and anchoring functions. Owing to its structural diversity, the cutting head performance of a bolter miner varies.
Shuo QIAO, Yimin XIA, Zaizheng LIU, Jinshu LIU, Bo NING, Ailun WANG   +5 more
doaj   +1 more source

Towards an Operational Definition of Lean Construction Onsite [PDF]

, 2015
Through literature review and drawing from a combined professional experience of over 20 years of lean construction implementation, this paper investigates the key success factor for the automotive industry’s uptake of lean production to see what the ...
Koskela, Lauri, Sjögren Leong, Michelle, Ward, Steve   +2 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Overview and Analysis of the Text Mining Applications in the Construction Industry

, 2022
Hang Yan, Mingxue Ma, Ying Wu, Hongqin Fan, Chao Dong   +4 more
openalex   +1 more source