Results 71 to 80 of about 1,991,723 (306)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Analysis of the dynamic fragmentation process of debris flow in the Madaling landslide in Duyun, Guizhou

Zhongguo dizhi zaihai yu fangzhi xuebao
The presence of underlying mined-out layer and developed joints have an important impact on the fragmentation process of landslide collapse. In order to further explore the cutting and fragmentation effects and characteristics of joints on rock masses ...
Jie MA, Yaoming ZHANG, Wengang YU, Chunling WANG, Guofeng ZHANG, Junyi HE   +5 more
doaj   +1 more source

Trade credit in the UK construction industry: an empirical analysis of construction contractor financial positioning and performance [PDF]

, 2013
Research commissioned by the Department for Business, Innovation & Skills (BIS) to inform analysis for the ‘Industrial Strategy for Construction’. It explores the availability of trade credit for UK construction firms and how they rely upon it to support
Ive, G, Murray, A
core  

Barriers to women in the UK construction industry [PDF]

, 2010
Purpose – This paper aims to identify the main barriers that lead to the under-representation of women in the UK construction industry. The study, funded by ConstructionSkills, seeks to explore the issues that women face and investigate the potential ...
Harris, K, McDermott, P, Stewart, R, Thomas, A, Worrall, LJ   +4 more
core   +2 more sources

Construction Industry

, 2018
coverage ...
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Preparation and performance evaluation of non-sticky wheel emulsified asphalt

Scientific Reports
To address the issue of traditional emulsified asphalt easily adhering to wheels during construction, thereby causing interlayer bonding failure, a novel non-stick wheel emulsified asphalt was developed using 30# base asphalt as the raw material.
Jia Wang, Changyu Pu, Huabao Ma, Chao Sun   +3 more
doaj   +1 more source

Experimental and theoretical study on flexural performance of lightweight sandwich panels using FRP connectors

Case Studies in Construction Materials
Prefabricated concrete sandwich panels are crucial components in the construction of prefabricated buildings, providing essential functions such as load-bearing capacity, thermal insulation, and fire resistance.
Nengming CHENG, Juntian TANG, Peng FENG, Zhihao HAO, Yaolin ZHANG, Mingyuan CHANG   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source