Results 101 to 110 of about 15,133 (217)
Journal of Engineering and Sustainable Development, 2017 This study is concerned with the effect of curing methods and early curing on the some properties of high performance lightweight concrete HPLWC that exposed to effects of hot dry weather conditions to improve the performance of concrete structures ...
Hisham Khaled Ahmed +2 more
doaj
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
BuildingsConstruction management, from the contractor’s perspective, is led by the Construction Manager (CM). The work motivation and leadership style of the CM are critical variables for the successful execution of construction projects.
Marcelo Villena Manzanares +1 more
doaj +1 more source
Project financing in construction projects
, 2020 Proje Finansmanı, uzun vadeli alt yapı, endüstriyel veya büyük çaptaki projelerin kamu projelerinin yapımı için sağlanan kredi olarak tanımlanmaktadır. Bu finansman modelinde, diğer finansman modellerinden farklı olarak, kredi geri ödemesi için gipotek edilen kaynaklar krediyi kullanan tarafın varlıkları değil, projeden elde edilecek olan nakit ...
openaire +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Constructive Use of Holographic Projections
, 2009 24 pages, refereces and footnotes added, last two sections expanded Dedicated to Klaus Fredenhagen on the occasion of his 60th birthday. To appear in: "Quantum field theory --Competitive Methods", Birkhhaeuser Basel, 2008, Eds. B. Fauser, J. Tolksdorf and E.
openaire +2 more sources
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source