Results 101 to 110 of about 5,487,587 (291)
Acta Structilia, 2012 The estimation of contract completion time has always been inaccurate despite there being a need for certainty regarding the completion of projects. This article reports on an investigation of the relationship between initial and final contract time with
Olatunji Ayodeji Aiyetan +2 more
doaj
Development of methodology for time management of construction projects
Инженерно-строительный журнал, 2016 This article dwells upon the issues of providing project timely completion as well as key project milestones. In many cases project deadline exceed leads to catastrophic outcomes for the aims and results of the project.
S. V. Bovteev, S.V. Kanyukova
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Construction of Complex Network with Multiple Time Series Relevance
Information, 2018 Multivariate time series data, which comprise a set of ordered observations for multiple variables, are pervasively generated in weather conditions, traffic, financial stocks, etc. Therefore, it is of great significance to analyze the correlation between
Zongwen Huang +4 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Construction of N-body time-symmetric initial data sets in general relativity
, 2009 Given a collection of N asymptotically Euclidean ends with zero scalar curvature, we construct a Riemannian manifold with zero scalar curvature and one asymptotically Euclidean end, whose boundary has a neighborhood isometric to the disjoint union of a ...
Chruściel, Piotr T. +2 more
core +1 more source