Results 91 to 100 of about 5,889,389 (341)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Indigenous Knowledge about Consumption of Edible Insects in South Africa [PDF]

, 2020
Zabentungwa T. Hlongwane, Rob Slotow, Thinandavha C. Munyai   +2 more
openalex   +1 more source

Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study [PDF]

, 2021
Xie Xiao-qian, Yan Geng, Qijie Guan, Yilin Ren, Lin Guo, Qiqi Lv, Zhen‐Ming Lu, Jin‐Song Shi, Zhenghong Xu   +8 more
openalex   +1 more source

Consumption [PDF]

Macroeconomic research on consumption has been influenced profoundly by rational expectations. First, rational expectations together with the hypothesis of constant expected real interest rates implies that consumption should evolve as a random walk ...
Robert E. Hall
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Understanding the underlying systems dynamics contributing to the continued predominance of the unhealthy motorway food environment in the Netherlands: identifying leverage points and actions for change

BMC Medicine
Background Motorway food environments are dominated by roadside restaurants and petrol station stores offering predominantly unhealthy quick-service meals and foods for on-the-go consumption.
Lisanne Geboers, Coosje Dijkstra, Frédérique C. Rongen, Sanne K. Djojosoeparto, Maartje P. Poelman   +4 more
doaj   +1 more source

Consumption inequality and intrahousehold allocations [PDF]

, 2007
The current literature on consumption inequality treats all adults within the household equally, making the implicit assumption that all consumption inequality is between, not within, households.
Lise, JS, Seitz, S
core  

Predicting fuel energy consumption during earthworks [PDF]

, 2016
This research contributes to the assessment of on-site fuel consumption and the resulting carbon dioxide emissions due to earthworks-related processes in residential building projects, prior to the start of the construction phase.
Bossi, Benedetta, Casals Casanova, Miquel, Gangolells Solanellas, Marta, Trani, Marco Lorenzo Agostino   +3 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

An Analysis of the Energy Consumption Forecasting Problem in Smart Buildings Using LSTM [PDF]

, 2022
Daniela Durand, José Aguilar, María D. R‐Moreno   +2 more
openalex   +1 more source