Results 51 to 60 of about 3,458,657 (253)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Production-based and consumption-based approaches for the energy-growth-environment nexus: Evidence from Asian countries

, 2020
The number of studies that highlight demand-side and supply-side of environmental degradation are quite limited in the literature. The aim of this study is to analyze the energy-growth-environment nexus in cooperation with globalization, urbanization ...
Taskin, D., Pandey, S., Pandey, Sweety, Dogan, Eyup, Taskin, Dilvin, Dogan, E.   +5 more
core   +1 more source

Voicing residents’ perception of (commercial) food cues in outdoor public spaces: a photovoice study

BMC Public Health
Background (Commercial) food cues in outdoor public spaces are environmental drivers of unhealthy diets. This study aimed to explore residents’ perceptions of food cues in outdoor public spaces in relation to their perceived food environment, eating ...
Tamika M. Wopereis, Kirsten J. Roman, Sanne K. Djojosoeparto, Maartje P. Poelman   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Peer effects in consumption in India: An instrumental variables approach using negative idiosyncratic shocks [PDF]

, 2019
© 2018 Elsevier Ltd This paper examines peer effects in consumption in context of a less developed country. Specifically, the question that I seek to answer is whether consumption expenditure of a household is influenced by that of its peers in a less ...
Roychowdhury, Punarjit
core   +1 more source

The incidence and prevalence of hospital-acquired (carbapenem-resistant) Acinetobacter baumannii in Europe, Eastern Mediterranean and Africa: a systematic review and meta-analysis

Emerging Microbes and Infections, 2019
Due to therapeutic challenges, hospital-acquired infections (HAIs) caused by Acinetobacter baumannii (HA-AB), particularly carbapenem-resistant strains (HA-CRAB) pose a serious health threat to patients worldwide.
Olaniyi Ayobami, Niklas Willrich, Thomas Harder, Iruka N. Okeke, Tim Eckmanns, Robby Markwart   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The epidemiology of carbapenem-non-susceptible Acinetobacter species in Europe: analysis of EARS-Net data from 2013 to 2017

Antimicrobial Resistance and Infection Control, 2020
Background Due to limited therapeutic options and their association with high mortality and morbidity, carbapenem-non-susceptible Acinetobacter spp. (CNA) are of significant public health importance.
Olaniyi Ayobami, Niklas Willrich, Beneditta Suwono, Tim Eckmanns, Robby Markwart   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Identifying mechanisms that shape the food environment in long-term healthcare facilities in the Netherlands: a participatory system dynamics approach

BMC Public Health
Background Creating healthy and sustainable food environments within long-term healthcare facilities asks for a systemic approach. This study aimed to: (1) identify system dynamics underlying the food environment of long-term healthcare facilities, (2 ...
Joline J. Wierda, S. Coosje Dijkstra, Tamika M. Wopereis, Sanne K. Djojosoeparto, Maartje P. Poelman   +4 more
doaj   +1 more source