Results 61 to 70 of about 5,771,225 (338)

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Determinants, behaviour change techniques and pedagogical approaches used in secondary school-based food and nutrition programmes: a qualitative study of the SWITCH project

BMC Public Health
Background Food and nutrition programmes at secondary schools have the potential to improve public and planetary health, as they target a wide range of adolescents.
Anouk Mesch, Madelief Engels, Sanne Raghoebar, Laura H. H. Winkens, Judith Gulikers, Renate Wesselink, Annemien Haveman-Nies   +6 more
doaj   +1 more source

The incidence and prevalence of hospital-acquired (carbapenem-resistant) Acinetobacter baumannii in Europe, Eastern Mediterranean and Africa: a systematic review and meta-analysis

Emerging Microbes and Infections, 2019
Due to therapeutic challenges, hospital-acquired infections (HAIs) caused by Acinetobacter baumannii (HA-AB), particularly carbapenem-resistant strains (HA-CRAB) pose a serious health threat to patients worldwide.
Olaniyi Ayobami, Niklas Willrich, Thomas Harder, Iruka N. Okeke, Tim Eckmanns, Robby Markwart   +5 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Reducing Power Consumption in Backbone Networks [PDF]

, 2009
—According to several studies, the power consumption of the Internet accounts for up to 10 % of the worldwide energy consumption, and several initiatives are being put into place to reduce the power consumption of the ICT sector in general. To this goal,
Chiaraviglio, Luca, Mellia, Marco, Neri, Fabio   +2 more
core   +2 more sources

The food environment through the eyes of adolescents: exploring socioecological factors and opportunities for healthy and sustainable food choices

BMC Public Health
Background Although it is evident that current food environments do not facilitate healthy and sustainable diets, it is still largely unknown how adolescents navigate their food environments during the school week. This study explored how adolescents, in
Anouk Mesch, Femke Hoefnagels, Judith Gulikers, Renate Wesselink, Laura H.H. Winkens, Sanne Raghoebar, Annemien Haveman-Nies   +6 more
doaj   +1 more source

The epidemiology of carbapenem-non-susceptible Acinetobacter species in Europe: analysis of EARS-Net data from 2013 to 2017

Antimicrobial Resistance and Infection Control, 2020
Background Due to limited therapeutic options and their association with high mortality and morbidity, carbapenem-non-susceptible Acinetobacter spp. (CNA) are of significant public health importance.
Olaniyi Ayobami, Niklas Willrich, Beneditta Suwono, Tim Eckmanns, Robby Markwart   +4 more
doaj   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Considering a Consumption Tax [PDF]

, 2006
A combination of electronic commerce and the Flat Tax could eliminate the IRS as we know ...
Goldberg, Daniel S.
core   +1 more source

Consumption Smoothing and Vulnerability in Russia [PDF]

, 2007
Applying bootstrapped quantile regression to the Russian Longitudinal Monitoring Survey (RLMS) data, we examine the channels through which individuals experience and seek to cope with changes in consumption.
Gerry, Christopher, Li, Carmen A.
core   +1 more source