Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
A Three-Dimensional Elastic-Plastic Contact Analysis of Vickers Indenter on a Deep Drawing Quality Steel Sheet. [PDF]
Materials (Basel), 2019 Trzepiecinski T, Lemu HG.
europepmc +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
FEBS Open Bio, EarlyView.Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source
Virtual stenting with simplex mesh and mechanical contact analysis for real-time planning of thoracic endovascular aortic repair. [PDF]
Theranostics, 2018 Chen D +11 more
europepmc +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
Transmission Error Analysis of Cycloid Pin Wheel Based on Geometric Contact Algorithm
Jixie chuandongIn response to the problem that the error value is usually set as a constant value in the tooth contact analysis (TCA) model of cycloidal needle tooth transmission, which makes the calculation results unreasonable, and the calculation does not converge ...
Huang Yuelei, Zhang Yinghui, He Weidong
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Research on the sliding friction associated spur-face gear meshing efficiency based on the loaded tooth contact analysis. [PDF]
PLoS One, 2018 Dong H, Liu ZY, Duan LL, Hu YH.
europepmc +1 more source
FEBS Open Bio, EarlyView.The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez +4 more
wiley +1 more source
Geometric parameterisation of pelvic bone and cartilage in contact analysis of the natural hip: an initial study. [PDF]
Proc Inst Mech Eng H, 2015 Hua X +4 more
europepmc +1 more source