Results 81 to 90 of about 1,993,192 (267)
Research on the Wheel-rail Matching in High-speed Railway under Different Traction Conditions
机车电传动, 2018 In order to study the contact characteristics of the new rail profile and the high-speed EMUs wheel profiles, the profiles matching between LMA, S1002CN, XP55 wheel and 60D, 60N rail in the middle position had been proceeded.
WANG Xueping, ZHANG Jun, MA He
doaj
Analysis of a dynamic thermo-elastic-viscoplastic contact problem
Electronic Journal of Qualitative Theory of Differential Equations, 2013 We consider a dynamic frictionless contact problem for thermo-elastic-viscoplastic materials with damage and adhesion. The contact is modeled with normal compliance condition.
Abdelaziz Azeb Ahmed +1 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A sensitivity analysis for frictionless contact problems
Computer Assisted Methods in Engineering and Science, 2023 A sensitivity analysis method for elasto-plastic contact problems with large deformation is developed based on two contact constraint methods, i.e., the Lagrange multiplier and penalty methods.
Xian Chen +2 more
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
THIN-WALLED FOUR-POINT CONTACT BALL BEARING CONTACT FINITE ELEMENT ANALYSIS
Jixie qiangdu, 2018 Based on the ANSYS finite element software,the method of dividing the contact area of the four point contact ball bearing is proposed. Establish a uniform thin four point contact ball bearing 1/2 single rolling and ring and the bearing finite element ...
WU Li +3 more
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Analysis of Contact Wheel and Tool Interaction in Belt Grinding
Journal of Machine EngineeringThe belt grinding process is gaining an increasing importance in the industrial sector. Due to its high flexibility regarding the range of workpiece materials and its adaptability to various, even geometrically complex workpiece shapes and designs, belt ...
Julian Wolfgang Henning +2 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source