Results 91 to 100 of about 2,202,475 (315)

Finite element modelling and load share analysis for involute worm gears with localised tooth contact

open access: yes, 2001
A new approach has been developed by the authors to estimate the load share of worm gear drives, and to calculate the instantaneous tooth meshing stiffness and loaded transmission errors. In the approach, the finite element (FE) modelling is based on the
Gentle, CR, Su, D, Yang, F
core  

Three-dimensional finite analysis of acetabular contact pressure and contact area during normal walking

open access: yesAsian Journal of Surgery, 2017
Background: This study aims to analyze the contact areas and pressure distributions between the femoral head and mortar during normal walking using a three-dimensional finite element model (3D-FEM).
Guangye Wang   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Intergroup contact buffers against the intergenerational transmission of authoritarianism and racial prejudice [PDF]

open access: yes, 2012
The present study focused on the buffering role of positive intergroup contact in the intergenerational transmission of authoritarianism and racial prejudice in a sample of adolescents and one of their parents.
Van Hiel, Alain   +3 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

The use of a non-classical friction law in finite-element analysis of contact problems

open access: yes, 1983
Bibliography: leaves 82-84.In this thesis a description is given of the numerical treatment of contact problems in elasticity. Frictional effects on the contact surface are modelled by using a nonlocal, nonlinear friction law.
Bolt, Andrew Clifford
core  

Refining intra-protein contact prediction by graph analysis

open access: yesBMC Bioinformatics, 2007
Background Accurate prediction of intra-protein residue contacts from sequence information will allow the prediction of protein structures. Basic predictions of such specific contacts can be further refined by jointly analyzing predicted contacts, and by
Eyal Eran   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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