Results 51 to 60 of about 2,202,475 (315)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Children’s contact services: key issues [PDF]
, 2015 Children’s Contact Services (CCSs) are designed to provide a safe, supervised environment for children to spend time with the parent they do not live with, or to facilitate the transfer of children from one parent to another, in circumstances where ...
Cathryn Hunter, Joanne Commerford
core
Elastic Contact Analysis of Shot-Peened Rough Surfaces
Lubricants, 2022 Shot peening can effectively improve the mechanical performance of metal components, and thus has been widely employed in the engineering field. During the processing, the surface roughness of treated components will be completely changed, which could ...
Wanlin Dai, Weike Yuan, Gangfeng Wang
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Sibling placement and contact in out-of-home care [PDF]
, 2015 Many children and young people do not live with all of their siblings in out-of-home care, and contact with the siblings who are not placed with them is not always regular or easily accessed, according to this report.
CREATE Foundation
core
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Benchmarking Signorini and exponential contact laws for an industrial train brake squeal application [PDF]
, 2012 Contact representation of structure interactions for finite element models is nowadays of great interest in the industry. Two contact modellig strategies exist in the literature, either based on a perfect contact with no interpenetration of structures at
VERMOT DES ROCHES, Guillaume +3 more
core
Analysis of a frictionless contact problem for elastic-viscoplastic materials
, 2012 We consider a dynamic frictionless contact problem for elastic-viscoplastic materials with damage. The contact is modelled with normal compliance condition.
Selmani, Mohamed, Selmani, Lynda
core +1 more source